Evidence map›Paper›PMID 37662376›Full record

ArticlebioRxiv : the preprint server for biology2023

Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses.

Federica Vecchio, Alexia Carré, Daniil Korenkov, Zhicheng Zhou, Paola Apaolaza, Soile Tuomela, Orlando Burgos-Morales, Isaac Snowhite, Javier Perez-Hernandez, Barbara Brandao and 25 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors at 11 institutions in 6 countries.

Federica VecchioUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.
Alexia CarréUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.
Daniil KorenkovUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.
Zhicheng ZhouUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.
Paola ApaolazaInstitute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany.
Soile TuomelaCenter for Infectious Medicine, Department of medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Orlando Burgos-MoralesUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.
Isaac SnowhiteDiabetes Research Institute, Leonard Miller School of Medicine, University of Miami, FL, USA.
Javier Perez-HernandezUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.
Barbara BrandaoUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.
Georgia AfonsoUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.
Clémentine HalliezUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.
John KaddisDepartment of Diabetes Immunology, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Sally C KentUniversity of Massachusetts Medical Chan School, Diabetes Center of Excellence, Department of Medicine, Worcester, MA, USA.
Maki NakayamaBarbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO, USA.
Sarah J RichardsonIslet Biology Exeter (IBEx), Exeter Centre of Excellence for Diabetes Research (EXCEED), Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK.
Joelle VinhESPCI Paris, PSL University, Spectrométrie de Masse Biologique et Protéomique, CNRS UMR8249, Paris, France.
Yann VerdierESPCI Paris, PSL University, Spectrométrie de Masse Biologique et Protéomique, CNRS UMR8249, Paris, France.
Jutta LaihoTampere University, Faculty of Medicine and Health Technology and Fimlab Laboratories, Tampere, Finland.
Raphael ScharfmannUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.
Michele SolimenaPaul Langerhans Institute, Technical University Dresden, Germany.
Zuzana MarinicovaPaul Langerhans Institute, Technical University Dresden, Germany.
Elise BismuthAssistance Publique Hôpitaux de Paris, Service d'Endocrinologie Pédiatrique, Robert Debré Hospital, Paris, France.
Nadine LucidarmeAssistance Publique Hôpitaux de Paris, Service de Pédiatrie, Jean Verdier Hospital, Bondy, France.
Janine SanchezDepartment of Pediatrics, Division of pediatric Endocrinology, Leonard Miller School of Medicine, University of Miami, FL, USA.
Carmen BustamanteDepartment of Pediatrics, Division of pediatric Endocrinology, Leonard Miller School of Medicine, University of Miami, FL, USA.
Patricia GomezDepartment of Pediatrics, Division of pediatric Endocrinology, Leonard Miller School of Medicine, University of Miami, FL, USA.
Soren BuusPanum Institute, Department of International Health, Immunology and Microbiology, Copenhagen, Denmark.
nPOD-Virus Working Group
Sylvaine YouUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.
Alberto PuglieseDiabetes Research Institute, Leonard Miller School of Medicine, University of Miami, FL, USA.
Heikki HyotyTampere University, Faculty of Medicine and Health Technology and Fimlab Laboratories, Tampere, Finland.
Teresa Rodriguez-CalvoInstitute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany.
Malin Flodstrom-TullbergCenter for Infectious Medicine, Department of medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Roberto MalloneUniversité Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.
Centre National de la Recherche Scientifique · FRUniversity of Miami · USAssistance Publique – Hôpitaux de Paris · FRKarolinska University Hospital · SEPaul Langerhans Institute Dresden · DETampere University · FICity of Hope · USHelmholtz Zentrum München · DEUniversity of Colorado Denver · USUniversity of Exeter · GBUniversity of Massachusetts Chan Medical School · US

Funding

Molecular Dissection of Insulin Targeting in Anti-Islet AutoimmunityR01DK099317 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI AARON W MICHELS, Maki Nakayama · 2013 to 2026
$5.3M
NIDDK NIH HHS R01 DK099317
6 · The paper itself

Abstract

Coxsackievirus B (CVB) infection of pancreatic β cells is associated with β-cell autoimmunity. We investigated how CVB impacts human β cells and anti-CVB T-cell responses. β cells were efficiently infected by CVB

Indexed as

cytotoxic T lymphocytesEnterovirusepitopesglutamic acid decarboxylaseHLAimmunopeptidomemimicrytype 1 diabetesvaccination

Identifiers

PMID37662376
PMCPMC10473604
OpenAlexW4386028328

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.