Evidence map›Paper›PMID 37662324›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Clinical consequences of a polygenic predisposition to benign lower white blood cell counts: Consequences of benign WBC count genetics.

Jonathan D Mosley, John P Shelley, Alyson L Dickson, Jacy Zanussi, Laura L Daniel, Neil S Zheng, Lisa Bastarache, Wei-Qi Wei, Mingjian Shi, Gail P Jarvik and 18 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors at 10 institutions in 1 country.

Jonathan D MosleyDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
John P ShelleyDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Alyson L DicksonDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Jacy ZanussiDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Laura L DanielDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Neil S ZhengDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Lisa BastaracheDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Wei-Qi WeiDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Mingjian ShiDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Gail P JarvikDepartment of Genome Sciences, University of Washington Medical Center, Seattle WA, USA.
Elisabeth A RosenthalDepartment of Medicine (Medical Genetics), University of Washington Medical Center, Seattle WA, USA.
Atlas KhanDivision of Nephrology, Dept of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY.
Alborz SherafatiDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester MN USA.
Iftikhar J KulloDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester MN USA.
Theresa L WalunasDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Joe GlessnerDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Hakon HakonarsonDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nancy J CoxDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Dan M RodenDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Stephan G FrangakisDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Brett VanderwerffDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
C Michael SteinDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Sara L Van DriestDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Scott C BorinsteinDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Xiao-Ou ShuDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Matthew ZawistowskiDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Cecilia P ChungDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Vivian K KawaiDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Vanderbilt University Medical Center · USUniversity of Michigan · USMayo Clinic · USUniversity of Washington Medical Center · USChildren's Hospital of Philadelphia · USColumbia University · USNorthwestern University · USUniversity of Pennsylvania · USVanderbilt University · USYale University · US

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
JH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2M
A Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4M
Pharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4M
Genomic Basis of Susceptibility to COVID-19 Infection and its ComplicationsU01HG006379 · NHGRI · MAYO CLINIC ROCHESTER · PI Richard R. Sharp · 2011 to 2026
$16.5M
Understanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2015 to 2019
$13.0M
The Genetic Epemiology of Multiple SclerosisR01NS032830 · NINDS · VANDERBILT UNIVERSITY · PI HAINES, JONATHAN L · 1995 to 2010
$8.9M
Epidemiologic Architecture for Genes Linked to Environment (EAGLE)U01HG004798 · NHGRI · VANDERBILT UNIVERSITY · PI CRAWFORD, DANA C · 2008 to 2013
$8.8M
Vanderbilt Genome-Electronic Records (VGER) ProjectU01HG011181 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DAN M RODEN, Digna R Velez Edwards · 2020 to 2026
$7.0M
NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NCRR NIH HHS S10 RR025141NCRR NIH HHS UL1 RR024975NHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004798NHGRI NIH HHS U01 HG006375NHGRI NIH HHS U01 HG006378NHGRI NIH HHS U01 HG006379NHGRI NIH HHS U01 HG006380NHGRI NIH HHS U01 HG006382NHGRI NIH HHS U01 HG006385NHGRI NIH HHS U01 HG006388NHGRI NIH HHS U01 HG006389NHGRI NIH HHS U01 HG006828NHGRI NIH HHS U01 HG006830NHGRI NIH HHS U01 HG011181NHLBI NIH HHS U19 HL065962NIAMS NIH HHS K08 AR082454NIAMS NIH HHS R01 AR076516NICHD NIH HHS R01 HD074711NIGMS NIH HHS P50 GM115305NIGMS NIH HHS R01 GM126535NIGMS NIH HHS R01 GM130791NIGMS NIH HHS R35 GM131770NIGMS NIH HHS RC2 GM092618NIGMS NIH HHS T32 GM007347NINDS NIH HHS R01 NS032830
6 · The paper itself

Abstract

Polygenic variation unrelated to disease contributes to interindividual variation in baseline white blood cell (WBC) counts, but its clinical significance is undefined. We investigated the clinical consequences of a genetic predisposition toward lower WBC counts among 89,559 biobank participants from tertiary care centers using a polygenic score for WBC count (PGS

Indexed as

azathioprinebone marrow biopsypharmacogenomicspolygenic scoretaxaneWhite blood cell count

Identifiers

PMID37662324
PMCPMC10473820
OpenAlexW4386021025

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.