Evidence map›Paper›PMID 37662316›Full record

ArticlebioRxiv : the preprint server for biology2024

Bartosz Kula, Botond Antal, Corey Weistuch, Florian Gackière, Alexander Barre, Victor Velado, Jeffrey M Hubbard, Maria Kukley, Lilianne R Mujica-Parodi, Nathan A Smith

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Bartosz KulaDel Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester, School of Medicine and Dentistry, Rochester, USA.
Botond AntalDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, USA.
Corey WeistuchDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Florian GackièreNeuroservices Alliance, Les Jardins de l'Entreprise, Quartier de le Confrérie, Le Puy Ste Réparade, France.
Alexander BarreNeuroservices Alliance, Les Jardins de l'Entreprise, Quartier de le Confrérie, Le Puy Ste Réparade, France.
Victor VeladoCenter for Neuroscience Research, Children's National Research Institute, Children's National Hospital, Washington D.C., USA.
Jeffrey M HubbardNeuroservices Alliance, Les Jardins de l'Entreprise, Quartier de le Confrérie, Le Puy Ste Réparade, France.
Maria KukleyAchucarro Basque Center for Neuroscience, Leioa, Spain.
Lilianne R Mujica-ParodiDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, USA.ORCID 0000-0002-3752-5519
Nathan A SmithDel Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester, School of Medicine and Dentistry, Rochester, USA.ORCID 0000-0002-9254-5360
Children's National · USHarvard University · USIkerbasque · ESMemorial Sloan Kettering Cancer Center · USUniversity of Rochester · US

Funding

Astrocytes Modulate Synaptic Plasticity via NorepinephrineK01NS110981 · NINDS · UNIVERSITY OF ROCHESTER · PI SMITH, NATHAN A · 2019 to 2024
$1.1M
NINDS NIH HHS K01 NS110981
6 · The paper itself

Abstract

The brain primarily relies on glycolysis for mitochondrial respiration but switches to alternative fuels such as ketone bodies (KBs) when less glucose is available. Neuronal KB uptake, which does not rely on glucose transporter 4 (GLUT4) or insulin, has shown promising clinical applicability in alleviating the neurological and cognitive effects of disorders with hypometabolic components. However, the specific mechanisms by which such interventions affect neuronal functions are poorly understood. In this study, we pharmacologically blocked GLUT4 to investigate the effects of exogenous KB D-β-hydroxybutyrate (D-βHb) on mouse brain metabolism during acute insulin resistance (AIR). We found that both AIR and D-βHb had distinct impacts across neuronal compartments: AIR decreased synaptic activity and long-term potentiation (LTP) and impaired axonal conduction, synchronization, and action potential (AP) properties, while D-βHb rescued neuronal functions associated with axonal conduction, synchronization, and LTP.

Indexed as

beta-hydroxybutyrateGLUT4hippocampusinsulin resistanceketone bodies

Identifiers

PMID37662316
PMCPMC10473684
OpenAlexW4386121877

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.