Evidence map›Paper›PMID 37662313›Full record

ArticlebioRxiv : the preprint server for biology2023

Crystallographic and thermodynamic evidence of negative cooperativity of flavin and tryptophan binding in the flavin-dependent halogenases AbeH and BorH.

Md Ashaduzzaman, Kazi Lingkon, Aravinda J De Silva, John J Bellizzi

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Md AshaduzzamanDepartment of Chemistry and Biochemistry, The University of Toledo, Toledo OH 43606.
Kazi LingkonDepartment of Chemistry and Biochemistry, The University of Toledo, Toledo OH 43606.
Aravinda J De SilvaDepartment of Chemistry and Biochemistry, The University of Toledo, Toledo OH 43606.
John J BellizziDepartment of Chemistry and Biochemistry, The University of Toledo, Toledo OH 43606.
University of Toledo · US

Funding

Discovery and Characterization of Novel Halogenases from the Human Microbiome and from ArchaeaR15GM144877 · NIGMS · UNIVERSITY OF TOLEDO · PI BELLIZZI, JOHN J. · 2021 to 2025
$935k
NIGMS NIH HHS R15 GM144877
6 · The paper itself

Abstract

The flavin-dependent halogenase AbeH produces 5-chlorotryptophan in the biosynthetic pathway of the chlorinated bisindole alkaloid BE-54017. We report that

Indexed as

flavinfluorescence quenchinghalogenaseisothermal titration calorimetrynatural product biosynthesisnegative cooperativityX-ray structures

Identifiers

PMID37662313
PMCPMC10473636
OpenAlexW4386094165

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.