Evidence map›Paper›PMID 37662284›Full record

ArticlebioRxiv : the preprint server for biology2025

Cellular characterization of the mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells.

S D Zawieja, G A Pea, S E Broyhill, A Patro, K H Bromert, C E Norton, H J Kim, S K Sivasankaran, M Li, J A Castorena-Gonzalez and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

S D ZawiejaDept. of Medical Pharmacology & Physiology, University of Missouri, Columbia, Missouri.ORCID 0000-0003-4658-3179
G A PeaDept. of Medical Pharmacology & Physiology, University of Missouri, Columbia, Missouri.
S E BroyhillDept. of Medical Pharmacology & Physiology, University of Missouri, Columbia, Missouri.
A PatroDept. of Medical Pharmacology & Physiology, University of Missouri, Columbia, Missouri.
K H BromertDept. of Medical Pharmacology & Physiology, University of Missouri, Columbia, Missouri.
C E NortonDept. of Medical Pharmacology & Physiology, University of Missouri, Columbia, Missouri.
H J KimDept. of Medical Pharmacology & Physiology, University of Missouri, Columbia, Missouri.
S K SivasankaranBioinformatics and Analytics Core, Division of Research, Innovation and Impact, University of Missouri, Columbia, Missouri.ORCID 0000-0003-3037-6001
M LiDept. of Medical Pharmacology & Physiology, University of Missouri, Columbia, Missouri.
J A Castorena-GonzalezDept. of Pharmacology, Tulane University, New Orleans, Louisiana.ORCID 0000-0001-5252-375X
B T DrummSmooth Muscle Research Centre, Dundalk Institute of Technology, Dundalk, Co. Louth, A91 K584, Ireland.
M J DavisDept. of Medical Pharmacology & Physiology, University of Missouri, Columbia, Missouri.
University of Missouri · USDundalk Institute of Technology · IETulane University · US

Funding

Lymphatic pacemaking and pumping in lymphedema: function, dysfunction, and rescueR01HL122578 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI DAVIS, MICHAEL JOHN · 2015 to 2023
$4.1M
Trpv4 regulation of lymphatic vascular function: Implications in metabolic syndromeR01HL168568 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI Jorge Augusto Castorena · 2023 to 2026
$1.9M
Regulation of lymphatic muscle cell function by store operated calcium entry signalingR01HL175083 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Scott D. Zawieja · 2024 to 2026
$1.7M
The Regulation of Lymphatic Muscle Cell Pacemaking by Intracellular Calcium SignalsR00HL143198 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI ZAWIEJA, SCOTT D. · 2021 to 2023
$747k
Endothelial dependent mechanisms of lymphatic dysfunction in metabolic syndrome and type-2 diabetes associated with obesityR00HL141143 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI CASTORENA, JORGE AUGUSTO · 2020 to 2022
$746k
The Regulation of Lymphatic Muscle Cell Pacemaking by Intracellular Calcium SignalsK99HL143198 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI ZAWIEJA, SCOTT D. · 2019 to 2020
$203k
Endothelial dependent mechanisms of lymphatic dysfunction in metabolic syndrome and type-2 diabetes associated with obesityK99HL141143 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI CASTORENA, JORGE AUGUSTO · 2019 to 2020
$193k
NHLBI NIH HHS K99 HL141143NHLBI NIH HHS K99 HL143198NHLBI NIH HHS R00 HL141143NHLBI NIH HHS R00 HL143198NHLBI NIH HHS R01 HL122578NHLBI NIH HHS R01 HL168568NHLBI NIH HHS R01 HL175083
6 · The paper itself

Abstract

Collecting lymphatic vessels (cLVs) exhibit spontaneous contractions with a pressure-dependent frequency, but the identity of the lymphatic pacemaker cell is still debated. Here we combined immunofluorescence and scRNAseq analyses with electrophysiological methods to examine the cellular constituents of the mouse cLV wall and assess whether any cell type exhibited morphological and functional processes characteristic of pacemaker cells. We employed inducible Cre (iCre) mouse models to target specific cell populations including c-kitCreER

Indexed as

interstitial cells of Cajal like cellsLymphatic collecting vessellymphatic muscle cellmesenchymal stem cellspacemaking

Identifiers

PMID37662284
PMCPMC10473772
OpenAlexW4386187572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.