ArticlemedRxiv : the preprint server for health sciences2023
WHOLE GENOME SEQUENCING ANALYSIS OF BODY MASS INDEX IDENTIFIES NOVEL AFRICAN ANCESTRY-SPECIFIC RISK ALLELE.
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In one paragraph
Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
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Corrections and comments
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Authors and funding
123 authors at 20 institutions in 5 countries.
Xinruo ZhangDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Mariaelisa GraffDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Heather M HighlandDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nathalie ChamiThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hanfei XuDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.
Zhe WangThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kendra FerrierDivision of Biomedical Informatics and Personalized Medicine, School of Medicine University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Geetha ChittoorPopulation Health Sciences, Geisinger, Danville, PA, USA.
Navya S JosyulaPopulation Health Sciences, Geisinger, Danville, PA, USA.
Xihao LiDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Zilin LiBiostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA.
Matthew A AllisonDepartment of Family Medicine, Division of Preventive Medicine, The University of California San Diego, La Jolla, CA, USA.
Diane M BeckerDepartment of Medicine, General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Meher Preethi BoorgulaDepartment of Medicine, School of Medicine, University of Colorado, Aurora, CO, USA.
Donald W BowdenDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jai G BroomeDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Erin J ButhDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Christopher S CarlsonDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Kyong-Mi ChangThe Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Sameer ChavanDepartment of Medicine, School of Medicine, University of Colorado, Aurora, CO, USA.
Yen-Feng ChiuInstitute of Population Health Sciences, National Health Research Institutes, Taipei, Taiwan.
Lee-Ming ChuangDepartment of Internal Medicine, Division of Metabolism/Endocrinology, National Taiwan University Hospital, Taipei, Taiwan.
Matthew P ConomosDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Dawn L DeMeoDepartment of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Margaret DuEpidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ravindranath DuggiralaLife Sciences, College of Arts and Sciences, Texas A&M University-San Antonio, San Antonio, TX, USA.
Celeste EngDepartment of Medicine, Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA.
Alison E FohnerEpidemiology, Institute of Public Health Genetics, School of Public Health, University of Washington, Seattle, WA, USA.
Barry I FreedmanInternal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Melanie E GarrettDepartment of Medicine, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
Xiuqing GuoDepartment of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Chris HaimanPreventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Benjamin D HeavnerDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Bertha HidalgoDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA.
James E HixsonDepartment of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Yuk-Lam HoVeterans Affairs Boston Healthcare System, Boston, MA, USA.
Brian D HobbsDepartment of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Donglei HuDepartment of Medicine, Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA.
Qin HuiDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Chii-Min HwuDepartment of Medicine, Division of Endocrinology and Metabolism, Taipei Veterans General Hospital, Taipei, Taiwan, Taiwan.
Rebecca D JacksonEndocrinology, Ohio State University, Columbus, OH, USA.
Deepti JainDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Rita R KalyaniDepartment of Medicine, Endocrinology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Tanika N KellyDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
Ethan M LangeDivision of Biomedical Informatics and Personalized Medicine, School of Medicine University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Michael LeNoirDepartment of Pediatrics, Bay Area Pediatrics, Oakland, CA, USA.
Changwei LiDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Merry-Lynn N McDonaldDepartment of Medicine, Pulmonary, Allergy and Critical Care, University of Alabama at Birmingham, Birmingham, AL, USA.
Caitlin P McHughDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Alanna C MorrisonDepartment of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Take NaseriMinistry of Health, Government of Samoa, Apia, Samoa.
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
Jeffrey O'ConnellDepartment of Medicine, Program for Personalized and Genomic Medicine, University of Maryland, Baltimore, MD, USA.
Christopher J O'DonnellVeterans Affairs Boston Healthcare System, Boston, MA, USA.
Nicholette D PalmerDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
James S PankowDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
James A PerryDepartment of Medicine, School of Medicine, University of Maryland, Baltimore, MD, USA.
Ulrike PetersDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Michael H PreussThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
D C RaoDivision of Biostatistics, Washington University in St. Louis, St. Louis, MO, USA.
Elizabeth A ReganDepartment of Medicine, Rheumatology, National Jewish Health, Denver, CO, USA.
Sefuiva M ReupenaLutia I Puava Ae Mapu I Fagalele, Apia, Samoa.
Dan M RodenMedicine, Pharmacology, and Biomedical Informatics, Clinical Pharmacology and Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Jose Rodriguez-SantanaCentro de Neumologia Pediatrica, San Juan, PR, USA.
Colleen M SitlaniCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Hemant K TiwariDepartment of Biostatistics, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA.
Ramachandran S VasanDepartment of Medicine, School of Medicine, Boston University, Boston, MA, USA.
Zeyuan WangDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Daniel E WeeksDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Jennifer WesselDepartment of Epidemiology, Indiana University, Indianapolis, IN, USA.
Kerri L WigginsCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Lynne R WilkensEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Peter W F WilsonAtlanta VA Health Care System, Decatur, GA, USA.
Lisa R YanekDepartment of Medicine, General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Zachary T YonedaDepartment of Medicine, Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Sebastian ZöllnerDepartment of Biostatistics, Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Donna K ArnettDepartment of Epidemiology, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Allison E Ashley-KochDepartment of Medicine, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
Kathleen C BarnesDepartment of Medicine, School of Medicine, University of Colorado, Aurora, CO, USA.
John BlangeroHuman Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX, USA.
Eric BoerwinkleDepartment of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Esteban G BurchardBioengineering and Therapeutic Sciences and Medicine, Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA.
April P CarsonDepartment of Medicine, University of Mississippi, Jackson, MI, USA.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Yii-Der Ida ChenDepartment of Medical Genetics, Genomic Outcomes, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Joanne E CurranDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX, USA.
Myriam FornageBrown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Victor R GordeukDepartment of Medicine, School of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Jiang HeDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
Susan R HeckbertDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Lifang HouNorthwestern University, Chicago, IL, USA.
Marguerite R IrvinDepartment of Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Ryan L MinsterDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Braxton D MitchellDepartment of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland, Baltimore, MD, USA.
Mehdi NouraieDepartment of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Laura M RaffieldDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Alexander P ReinerDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Stephen S RichPublic Health Science, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Jerome I RotterDepartment of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
M Benjamin ShoemakerDepartment of Medicine, Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Nicholas L SmithDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Kent D TaylorDepartment of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Marilyn J TelenDepartment of Medicine, Hematology, Duke University Medical Center, Durham, NC, USA.
Scott T WeissDepartment of Medicine, Channing Division of Network Medicine, Harvard Medical School, Boston, MA, USA.
Yingze ZhangDepartment of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Nancy Heard-CostaFramingham Heart Study, School of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Yan V SunDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Xihong LinDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
L Adrienne CupplesDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.
Leslie A LangeDivision of Biomedical Informatics and Personalized Medicine, School of Medicine University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Ching-Ti LiuDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Anne E JusticePopulation Health Sciences, Geisinger, Danville, PA, USA.
University of Washington · USUniversity of Colorado Anschutz Medical Campus · USBoston University · USEmory University · USUniversity of Michigan · USUniversity of North Carolina at Chapel Hill · USBrigham and Women's Hospital · USUCLA Medical Center · USUniversity of Alabama at Birmingham · USUniversity of Pittsburgh · USDuke Medical Center · USFred Hutch Cancer Center · USGeisinger Health System · USHarvard University · USJohns Hopkins University · USThe University of Texas Health Science Center at Houston · USTulane University · USUniversity of California, San Francisco · USUniversity of Maryland, Baltimore · USVanderbilt University Medical Center · US
Funding
Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MUniversity of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Pallav Pokhrel · 1996 to 2026
$56.2MWORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WASHBURN, LISA K · 1992 to 2010
$35.2MTulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Katherine Teresa Mills · 2016 to 2026
$25.3MTranslating Molecular and Clinical Data to Population Lung Cancer Risk AssessmentU19CA203654 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Christopher I. Amos, Rayjean J. Hung · 2017 to 2026
$23.7MNew Approaches for Empowering Studies of Asthma in Populations of African DescentR01HL104608 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARNES, KATHLEEN C, KENNY, EIMEAR ELIZABETH · 2011 to 2022
$23.1MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7MHYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHYR01HL055673 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ARNETT, DONNA K · 1996 to 2016
$18.1MSystems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2016 to 2020
$12.6MGenetic and Environmental Determinants of TriglyceridesU01HL072524 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ARNETT, DONNA K · 2002 to 2008
$11.9MNorth Carolina Translational and Clinical Science Institute (NC TraCS) KL2KL2TR002490 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEINBERGER, MORRIS · 2018 to 2022
$11.0MStatistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
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Abstract
Obesity is a major public health crisis associated with high mortality rates. Previous genome-wide association studies (GWAS) investigating body mass index (BMI) have largely relied on imputed data from European individuals. This study leveraged whole-genome sequencing (WGS) data from 88,873 participants from the Trans-Omics for Precision Medicine (TOPMed) Program, of which 51% were of non-European population groups. We discovered 18 BMI-associated signals (
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