Evidence map›Paper›PMID 37662262›Full record

ArticlebioRxiv : the preprint server for biology2023

A Biotin Targeting Chimera (BioTAC) System to Map Small Molecule Interactomes

Andrew J Tao, Jiewei Jiang, Gillian E Gadbois, Pavitra Goyal, Bridget T Boyle, Elizabeth J Mumby, Samuel A Myers, Justin G English, Fleur M Ferguson

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Andrew J TaoDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093.
Jiewei JiangDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093.
Gillian E GadboisDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093.
Pavitra GoyalDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093.
Bridget T BoyleDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093.
Elizabeth J MumbyDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112.
Samuel A MyersLaboratory for Immunochemical Circuits, La Jolla Institute for Immunology, La Jolla, CA 92037.
Justin G EnglishDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112.
Fleur M FergusonDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093.
University of California San Diego · USUniversity of Utah · USLa Jolla Institute for Immunology · US

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
Molecular Biophysics Training Grant at UC San DiegoT32GM139795 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Galia Debelouchina, ELIZABETH A. KOMIVES · 2021 to 2026
$3.0M
Chemical Control of Misfolded Protein FateDP2NS132610 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FERGUSON, FLEUR MARCIA · 2022 to 2025
$2.4M
Directed Evolution of Cell-Type Specific On-Demand Signaling Control SystemsDP2GM146247 · NIGMS · UNIVERSITY OF UTAH · PI ENGLISH, JUSTIN G. · 2021 to 2024
$2.3M
NCI NIH HHS P30 CA023100NIGMS NIH HHS DP2 GM146247NIGMS NIH HHS T32 GM139795NINDS NIH HHS DP2 NS132610
6 · The paper itself

Abstract

Unbiased chemical biology strategies for direct readout of protein interactome remodelling by small molecules provide advantages over target-focused approaches, including the ability to detect previously unknown targets, and the inclusion of chemical off-compete controls leading to high-confidence identifications. We describe the BioTAC system, a small-molecule guided proximity labelling platform, to rapidly identify both direct and complexed small molecule binding proteins. The BioTAC system overcomes a limitation of current approaches, and supports identification of both inhibitor bound and molecular glue bound complexes.

Identifiers

PMID37662262
PMCPMC10473607
OpenAlexW4386056128

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.