Evidence map›Paper›PMID 37662241›Full record

ArticlebioRxiv : the preprint server for biology2023

Reprogramming of breast tumor-associated macrophages with modulation of arginine metabolism.

Veani Fernando, Xunzhen Zheng, Vandana Sharma, Saori Furuta

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Veani FernandoDepartment of Cell & Cancer Biology, College of Medicine and Life Sciences, University of Toledo Health Science Campus, 3000 Arlington Ave. Toledo, OH 43614, USA.
Xunzhen ZhengDepartment of Cell & Cancer Biology, College of Medicine and Life Sciences, University of Toledo Health Science Campus, 3000 Arlington Ave. Toledo, OH 43614, USA.
Vandana SharmaDepartment of Cell & Cancer Biology, College of Medicine and Life Sciences, University of Toledo Health Science Campus, 3000 Arlington Ave. Toledo, OH 43614, USA.
Saori FurutaDepartment of Cell & Cancer Biology, College of Medicine and Life Sciences, University of Toledo Health Science Campus, 3000 Arlington Ave. Toledo, OH 43614, USA.
University of Toledo · USMetroHealth Medical Center · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Normalizing arginine metabolism with sepiaptein for immunostimulatory-shift ofHER2+ breast cancerR01CA248304 · NCI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI FURUTA, SAORI · 2020 to 2024
$1.8M
Roles of gut-breast axis in breast pathophysiologyR21CA288449 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI FURUTA, SAORI · 2024 to 2025
$414k
NCI NIH HHS R01 CA248304NCI NIH HHS R21 CA288449
6 · The paper itself

Abstract

HER2+ breast tumors have abundant immune-suppressive cells, including M2-type tumor associated macrophages (TAMs). While TAMs consist of the immune-stimulatory M1-type and immune-suppressive M2-type, M1/M2-TAM ratio is reduced in immune-suppressive tumors, contributing to their immunotherapy refractoriness. M1 vs. M2-TAM formation depends on differential arginine metabolism, where M1-TAMs convert arginine to nitric oxide (NO) and M2-TAMs convert arginine to polyamines (PAs). We hypothesize that such distinct arginine metabolism in M1- vs M2-TAMs is attributed to different availability of BH

Indexed as

breast cancerHER2nitric oxidepolyaminestetrahydrobiopterin

Identifiers

PMID37662241
PMCPMC10473631
OpenAlexW4386067001

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.