Evidence map›Paper›PMID 37662229›Full record

ArticlebioRxiv : the preprint server for biology2025

Stratification of enterochromaffin cells by single-cell expression analysis.

Yan Song, Linda J Fothergill, Kari S Lee, Brandon Y Liu, Ada Koo, Mark Perelis, Shanti Diwakarla, Brid Callaghan, Jie Huang, Jill Wykosky and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Yan SongDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, United States.
Linda J FothergillDepartment of Anatomy & Physiology, University of Melbourne, Parkville, Victoria 3010, Australia.
Kari S LeeDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, United States.
Brandon Y LiuDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, United States.
Ada KooDepartment of Anatomy & Physiology, University of Melbourne, Parkville, Victoria 3010, Australia.
Mark PerelisDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, United States.
Shanti DiwakarlaDepartment of Anatomy & Physiology, University of Melbourne, Parkville, Victoria 3010, Australia.
Brid CallaghanDepartment of Anatomy & Physiology, University of Melbourne, Parkville, Victoria 3010, Australia.
Jie HuangTakeda Pharmaceuticals, San Diego, CA 92121, United States.
Jill WykoskyTakeda Pharmaceuticals, San Diego, CA 92121, United States.
John B FurnessDepartment of Anatomy & Physiology, University of Melbourne, Parkville, Victoria 3010, Australia.ORCID 0000-0002-0219-3438
Gene W YeoDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, United States.
The University of Melbourne · AUUniversity of California San Diego · USTakeda (United States) · US

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9M
Coupling of muscle blind-dependent RNA processing to the circadian clock in neuronal homeostasis and sleepF32HL143978 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PERELIS, MARK · 2019 to 2021
$146k
NCI NIH HHS P30 CA023100NHLBI NIH HHS F32 HL143978
6 · The paper itself

Abstract

Dynamic interactions between gut mucosal cells and the external environment are essential to maintain gut homeostasis. Enterochromaffin (EC) cells transduce both chemical and mechanical signals and produce 5-hydroxytryptamine (5-HT) to mediate disparate physiological responses. However, the molecular and cellular basis for functional diversity of ECs remains to be adequately defined. Here, we integrated single-cell transcriptomics with spatial image analysis to identify fourteen EC clusters that are topographically organized along the gut. Subtypes predicted to be sensitive to the chemical environment and mechanical forces were identified that express distinct transcription factors and hormones. A

Indexed as

5-HTchemosensorenterochromaffin cellsenteroendocrine cellsgutmechanosensorPiezo2sensoryserotoninsingle cell transcriptome analysis

Identifiers

PMID37662229
PMCPMC10473706
OpenAlexW4386156188

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.