Evidence map›Paper›PMID 37662187›Full record

ArticlebioRxiv : the preprint server for biology2023

Improved dual-color GRAB sensors for monitoring dopaminergic activity

Yizhou Zhuo, Bin Luo, Xinyang Yi, Hui Dong, Jinxia Wan, Ruyi Cai, John T Williams, Tongrui Qian, Malcolm G Campbell, Xiaolei Miao and 7 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Yizhou ZhuoState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Bin LuoState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Xinyang YiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Hui DongState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Jinxia WanState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Ruyi CaiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
John T WilliamsVollum Institute, Oregon Health and Science University, Portland, OR 97239, USA.
Tongrui QianState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Malcolm G CampbellCenter for Brain Science, Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.
Xiaolei MiaoState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Bozhi LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Yu WeiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Guochuan LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Huan WangState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Yu ZhengState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Mitsuko Watabe-UchidaCenter for Brain Science, Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.
Yulong LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Peking University · CNHarvard University · USCapital Medical University · CNOregon Health & Science University · US

Funding

COCAINE: EFFECTS ON SINGLE NEURONSR01DA004523 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 1987 to 2025
$7.6M
Novel fluorescent sensors for imaging neuromodulationU01NS113358 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI DAN, YANG, LI, YULONG · 2019 to 2022
$4.3M
Molecular Codes for the Establishment of Functionally Segregated Dopaminergic CircuitsR01MH125162 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI UMEMORI, HISASHI, WATABE-UCHIDA, MITSUKO · 2021 to 2025
$4.1M
Optimization of GPCR-based fluorescent sensors for large-scale multiplexed in vivo imaging of neuromodulationU01NS120824 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIRES, SAMUEL ANDREW, LI, YULONG · 2021 to 2024
$3.6M
Retinoic acid, homeostatic plasticity and cocaine cravingR01DA049930 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WOLF, MARINA ELIZABETH · 2020 to 2024
$2.5M
Neural mechanisms of foraging decisionsF32MH126505 · NIMH · HARVARD UNIVERSITY · PI CAMPBELL, MALCOLM GUY · 2021 to 2023
$205k
NIDA NIH HHS R01 DA004523NIDA NIH HHS R01 DA049930NIMH NIH HHS F32 MH126505NIMH NIH HHS R01 MH125162NINDS NIH HHS U01 NS113358NINDS NIH HHS U01 NS120824
6 · The paper itself

Abstract

Dopamine (DA) plays multiple roles in a wide range of physiological and pathological processes via a vast network of dopaminergic projections. To fully dissect the spatiotemporal dynamics of DA release in both dense and sparsely innervated brain regions, we developed a series of green and red fluorescent GPCR activation-based DA (GRAB

Identifiers

PMID37662187
PMCPMC10473776
OpenAlexW4386156568

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.