Evidence map›Paper›PMID 37662034›Full record

ArticleFrontiers in neurology2023

Case report: Granzyme-B expression by T- and B- cells during severe AQP4-positive Neuromyelitis Optica spectrum disorder with fatal venous thromboembolism outcome.

Vinícius Oliveira Boldrini, Mariana Rabelo Brito, Raphael Patrício Silva Quintiliano, Lucas Scárdua Silva, Clarissa Lin Yasuda, Fernando Cendes, Alessandro Santos Farias, Alfredo Damasceno

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Terminally differentiated cytotoxic CD4CNS neuroscience & therapeutics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Vinícius Oliveira Boldrini *Neuroimaging Laboratory, Department of Neurology, University of Campinas, Campinas, São Paulo, Brazil.
Mariana Rabelo Brito *Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), University of Campinas, Campinas, São Paulo, Brazil.
Raphael Patrício Silva QuintilianoNeuroimmunology Unit, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
Lucas Scárdua SilvaNeuroimaging Laboratory, Department of Neurology, University of Campinas, Campinas, São Paulo, Brazil.
Clarissa Lin YasudaNeuroimaging Laboratory, Department of Neurology, University of Campinas, Campinas, São Paulo, Brazil.
Fernando CendesNeuroimaging Laboratory, Department of Neurology, University of Campinas, Campinas, São Paulo, Brazil.
Alessandro Santos FariasNeuroimmunology Unit, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
Alfredo DamascenoNeuroimaging Laboratory, Department of Neurology, University of Campinas, Campinas, São Paulo, Brazil.
Brazilian Institute of Neuroscience and Neurotechnology · BRUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The expression of serine protease granzyme-B (GzmB) by circulating CD8 Case presentation: Here, we describe an Aquaporin-4 positive (AQP4-positive) NMOSD patient who showed short myelitis (SM) and experienced a fatal pulmonary thromboembolism/lower extremity deep vein thrombosis during anti-CD20 treatment. Flow cytometry analyses from the peripheral blood revealed an enhanced cytotoxic behavior through circulating CD8 Conclusions: Fatal VTE may be a rare outcome, particularly in patients exhibiting SM, and may share poorly understood immunological mechanisms with AQP4-positive NMOSD severity.

Indexed as

anti CD20 monoclonal antibodyB cellsdeep vein thrombosis (DVT)Devic's syndromegranzyme-Bneuroinflammationpulmonary thromboembolismT lymphocytes

Identifiers

PMID37662034
PMCPMC10470460
OpenAlexW4385982274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.