Current Status and Problems of Newborn Infection Management at a Regional Hospital in Japan.

Takeshi Ninchoji, Masayo Okuno, Tomoko Kihara, Shigeki Takekida, Jun Maruyama

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Article in The Kobe journal of medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Takeshi NinchojiDepartment of Pediatrics, Harima-Himeji General Medical Hospital, Himeji, Japan.

Masayo OkunoDepartment of Pediatrics, Harima-Himeji General Medical Hospital, Himeji, Japan.

Tomoko KiharaDepartment of Obstetrics, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan.

Shigeki TakekidaDepartment of Pediatrics, Harima-Himeji General Medical Hospital, Himeji, Japan.

Jun MaruyamaDepartment of Pediatrics, Harima-Himeji General Medical Hospital, Himeji, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo clarify neonatal bacterial infection management in near term and term infants at a regional hospital in Japan.

methodsBetween 2018 and 2020, of 729 births, 236 patients who underwent blood examination at least twice by the age of 3 days, were included. Data from the medical records were analyzed retrospectively.

resultsMedian gestational age was 39 weeks, with 116 boys (49.1%) and 202 vaginal deliveries (85.6%). There were 37 cases of maternal group B streptococcus, 24 cases of premature rupture of membranes for more than 24 hours (PROM group), and 107 cases of amniotic fluid turbidity at birth (AFT group). Comparing groups, C-reactive protein (CRP) was significantly lower in the cesarean section (C/S) group (median 0.22 mg/dL; p < 0.05), and higher in the AFT group (0.44 mg/dL; p < 0.05). There were 77 positive cultures, (p < 0.05). Antibiotics were administered more frequently in cesarean section (19 cases; p < 0.001) and less in the PROM group (2 cases; p < 0.01).

conclusionsThere were no asymptomatic cases of CRP >2 mg/dL, and no cases of severe sepsis in normal neonatal deliveries. CRP levels were elevated in the AFT group, where culture was positive, but few antibiotics were administered. In the C/S group, antibiotics were administered if respiratory symptoms occurred unless the CRP level was high. Further, all patients in PROM group who received antibiotics had any symptoms, suggesting that routine blood tests may not be necessary.

Indexed as

Anti-Bacterial AgentsCesarean SectionC-Reactive ProteinFemaleHospitalsHumansInfantInfant, NewbornJapanMalePregnancyRetrospective StudiesAnti-Bacterial AgentsC-Reactive ProteinAntibioticsAntimicrobial resistant colonizationC-reactive proteinNeonatal infectionSepsis

Identifiers

PMID37661631

PMCPMC10695095

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.