ArticleJournal of atherosclerosis and thrombosis2024
Longitudinal Changes in Arterial Stiffness Associated with Physical Activity Intensity: The Toon Health Study.
Article in Journal of atherosclerosis and thrombosis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Higher Physical Activity Is Associated with Improved Ventricular-Arterial Coupling: Assessment Using the cfPWV/GLS Ratio in Primary Care-A Pilot Study.Journal of cardiovascular development and disease · 2025Article
- Physical Activity and Arterial Stiffness: A Narrative Review.Journal of clinical hypertension (Greenwich, Conn.) · 2025Review
- Association between sleep regularity and arterial stiffness among middle-age adults in Southwestern China.BMC public health · 2024Article
- Long term worsening of arterial stiffness from monitoring of QKD interval predicts the occurrence of cardiovascular events.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Association between ankle-brachial blood pressure index with all-cause and cardiovascular mortality in adults without arterial stiffness.BMC geriatrics · 2023Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsSeveral studies have revealed an association between moderate-to-vigorous physical activity (MVPA) and arterial stiffness, which is a known risk factor for cardiovascular disease. However, a few studies have considered the difference in the longitudinal effect of its intensity in a large general population. Therefore, we examined the effect of MVPA intensity on longitudinal changes in arterial stiffness.
methodsWe conducted a prospective cohort study involving 1,982 Japanese men and women. Arterial stiffness was measured using the cardio-ankle vascular index (CAVI) at baseline and 5-year follow-up. Physical activity was quantified using the Japan Arteriosclerosis Longitudinal Study Physical Activity Questionnaire and categorized into quartiles as MVPA levels. Linear mixed models were used to examine the differences at baseline and the rate of changes in CAVI associated with MVPA levels for over 5 years.
resultsThe multivariable-adjusted mean differences in CAVI at baseline were significantly lower in the third (β=-0.019 [95% confidence interval {CI}=-0.033 to -0.005]) and fourth (β=-0.018 [95% CI=-0.035 to -0.001]) quartiles of the MVPA group compared with those in the lowest quartile of MVPA, and the significant effect persisted 5 years later.
conclusionsIn summary, this study provides evidence to support the existence of a threshold for beneficial levels of MVPA in the prevention of arterial stiffness. Furthermore, this study suggests that exceeding this threshold may exert similar effects on arterial stiffness. These findings suggest that an optimal level of MVPA exists for preventing arterial stiffness, and exceeding this threshold may not engender additional benefits.
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