Evidence map›Paper›PMID 37661416›Full record

ArticleInternal medicine (Tokyo, Japan)2023

Venetoclax Combined with Azacytidine Can Be a First-line Treatment Option for Elderly Blastic Plasmacytoid Dendritic Cell Neoplasm.

Yasuhiro Nagate, Aya Nakaya, Ren Kamimura, Yumiko Hirose, Satoshi Nojima, Jiro Fujita, Eiji Kiyohara, Hirohiko Shibayama

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Blast and Bursts: Unveiling Splenic Rupture in Blastic Plasmacytoid Dendritic Cell Neoplasia.Journal of community hospital internal medicine perspectives · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yasuhiro NagateDepartment of Hematology, National Hospital Organization Osaka National Hospital, Japan.
Aya NakayaDepartment of Hematology, National Hospital Organization Osaka National Hospital, Japan.
Ren KamimuraDepartment of Hematology, National Hospital Organization Osaka National Hospital, Japan.
Yumiko HiroseDepartment of Central Laboratory and Surgical Pathology, National Hospital Organization Osaka National Hospital, Japan.
Satoshi NojimaDepartment of Pathology, Osaka University Graduate School of Medicine, Japan.
Jiro FujitaDepartment of Hematology and Oncology, Osaka University Graduate School of Medicine, Japan.
Eiji KiyoharaDepartment of Dermatology, Osaka University Graduate School of Medicine, Japan.
Hirohiko ShibayamaDepartment of Hematology, National Hospital Organization Osaka National Hospital, Japan.
Osaka National Hospital · JPOsaka University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An 84-year-old Japanese man was diagnosed with blastic plasmacytoid dendritic cell neoplasm (BPDCN). We administered combination therapy using venetoclax and azacytidine. We observed neutropenia (Grade 4), thrombocytopenia (Grade 2), and stomatitis (Grade 3). After six cycles of treatment, the BPDCN abnormal cells in the bone marrow specimen almost disappeared, and atypical cells were not detected in a skin biopsy. We propose venetoclax combined with azacytidine as a useful treatment approach in elderly patients, although clinicians should be mindful that therapeutic modifications may be essential to minimize and/or avoid adverse events.

Indexed as

Myeloproliferative DisordersNeutropeniaSkin NeoplasmsAgedAged, 80 and overAzacitidineBridged Bicyclo Compounds, HeterocyclicDendritic CellsHumansMaleSulfonamidesAzacitidineBridged Bicyclo Compounds, HeterocyclicSulfonamidesvenetoclaxazacytidineblastic plasmacytoid dendritic cell neoplasm (BPDCN)elderlyfirst-linevenetoclax

Identifiers

PMID37661416
PMCPMC10518555
OpenAlexW4386315592

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.