ArticleBMC biotechnology2023
Development of an itaconic acid production process with Ustilaginaceae on alternative feedstocks.
Article in BMC biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- In situ product removal via reactive extraction in itaconic acid fermentation with Ustilago cynodontis.Biotechnology for biofuels and bioproducts · 2026Article
- From beet molasses to malic acid: holistic development of fermentation and downstream process.Biotechnology for biofuels and bioproducts · 2026Article
- Acetate-containing supernatants from industrial off-gas cultivation enabling high-value product formation with established and emerging production organisms.Biotechnology for biofuels and bioproducts · 2026Article
- Online Monitoring of Oxygen Transfer Rate as a Versatile Tool for Fermentation Characterization and Optimization.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Integrating pH Value and Base Consumption in Online Monitoring of Organic Acid Production.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Extracellular Phosphate Availability ImpactsJournal of fungi (Basel, Switzerland) · 2025Article
- Mechanistic and structural insights into the itaconate-producingPNAS nexus · 2025Article
- Metabolic studies of Ogataea polymorpha using nine different corn steep liquors.BMC biotechnology · 2025Article
- Pitfalls in Early Bioprocess Development Using Shake Flask Cultivations.Engineering in life sciences · 2025Review
- Selective production of the itaconic acid-derived compounds 2-hydroxyparaconic and itatartaric acid.Metabolic engineering communications · 2024Article
- Efficient production of itaconic acid from the single-carbon substrate methanol with engineered Komagataella phaffii.Biotechnology for biofuels and bioproducts · 2024Article
- Phosphate limitation enhances malic acid production on nitrogen-rich molasses with Ustilago trichophora.Biotechnology for biofuels and bioproducts · 2024Article
- Establishing an itaconic acid production process with Ustilago species on the low-cost substrate starch.FEMS yeast research · 2024Article
- In situ adsorption of itaconic acid from fermentations of Ustilago cynodontis improves bioprocess efficiency.Biotechnology for biofuels and bioproducts · 2023Article
- High-sensitivity real-time monitoring of pH and respiration activity unveils metabolic dynamics in shake flask cultures.Biotechnology progressArticle
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently, Aspergillus terreus is used for the industrial production of itaconic acid. Although, alternative feedstock use in fermentations is crucial for cost-efficient and sustainable itaconic acid production, their utilisation with A. terreus most often requires expensive pretreatment. Ustilaginacea are robust alternatives for itaconic acid production, evading the challenges, including the pretreatment of crude feedstocks regarding reduction of manganese concentration, that A. terreus poses.
resultsIn this study, five different Ustilago strains were screened for their growth and production of itaconic acid on defined media. The most promising strains were then used to find a suitable alternative feedstock, based on the local food industry. U. cynodontis ITA Max pH, a highly engineered production strain, was selected to determine the biologically available nitrogen concentration in thick juice and molasses. Based on these findings, thick juice was chosen as feedstock to ensure the necessary nitrogen limitation for itaconic acid production. U. cynodontis ITA Max pH was further characterised regarding osmotolerance and product inhibition and a successful scale-up to a 2 L stirred tank reactor was accomplished. A titer of 106.4 g
conclusionsThis study demonstrates the utilisation of alternative feedstocks to produce ITA with Ustilaginaceae, without drawbacks in either titer or yield, compared to glucose fermentations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.