SynthesisBMC nephrology2023
Prevalence of physical frailty and impact on survival in patients with chronic kidney disease: a systematic review and meta-analysis.
Synthesis in BMC nephrology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Electromyographic findings and frailty in hemodialysis vs peritoneal dialysis patients.Renal failure · 2026Article
- Recommendations for the management of frailty in chronic kidney disease: a consensus report.Nature reviews. Nephrology · 2026Review
- Frailty in Cardiorenal Care: A Geriatric Perspective on the 2026 European Society of Cardiology Guidelines.Cureus · 2026Article
- The Usefulness of Falls Efficacy Scale-International in Predicting Falls in Chronic Kidney Disease Patients.Journal of clinical medicine · 2026Article
- Renal function and comprehensive frailty in community-dwelling older adults: cross-sectional and longitudinal analyses.Clinical and experimental nephrology · 2026Article
- Association of physical activity and life space with cognitive frailty in patients on hemodialysis: the REPnet-HD study.International urology and nephrology · 2026Article
- Article
- Chronic Kidney Disease and Unmet Needs for Comprehensive Rehabilitation in Australia.The Medical journal of Australia · 2026Review
- Usage Intention Toward an Interactive Smart Mirror Exercise Program Among Community-Dwelling Older Adults: An Application of the Decomposed Theory of Planned Behavior.Healthcare (Basel, Switzerland) · 2026Article
- Article
- The Role of Brain Structure in Explaining Physical Functioning in Male Veterans With Impaired Kidney Function.Journal of the American Geriatrics Society · 2026Article
- Reassessing CKD staging in the elderly: methodological and clinical concerns.International urology and nephrology · 2026Article
- Frailty in Focus: A Scoping Review of Frailty Instruments from the Kidney Disease Aging Research Collaborative.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- How frailty index impacts death in chronic kidney disease: A retrospective observational investigation.PloS one · 2026Observational
- Chronic kidney Disease overall survival prediction model based on frailty index score: construction and validation using NHANES data.Renal failure · 2025Article
- Frailty and peripheral neuropathy in hemodialysis patients: clinical and electrophysiological correlations.Renal failure · 2025Article
- Genetic and metabolomic pathways linking frailty, chronic kidney disease, and kidney failure: a Mendelian randomization and multi-omics analysis.Renal failure · 2025Article
- Outcomes of patients in a pre-dialysis clinic and implications for shared decision making.Clinical kidney journal · 2025Article
- Quality of life experience in physically frail people on renal dialysis: A qualitative meta-synthesis on the difficulties and resources for better health care.International journal of nursing sciences · 2025Review
- Frailty in Adults with CKD and Validation of the Kidney Failure Risk Equation in Frailty Subgroups.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty is common in chronic kidney disease (CKD) patients and becomes more prevalent as kidney disease progresses. This study aimed to investigate the prevalence of physical frailty and quantify the relationship between frailty and mortality risk in patients with CKD.
methodsPubMed, Web of Science, Embase, Cochrane Central Register of Controlled Trials, Clinicaltrial.gov, and major renal academic conferences were systematically searched, and additional references to relevant articles were manually searched. The prevalence of physical frailty and the risk of mortality based on random-effects models were assessed using percentages and hazard ratio (HR) with a 95% confidence interval (CI).
resultsA total of 139 articles, including 1,675,482 participants, met the eligibility criteria for the meta-analysis. The results showed that 34.5% (95% CI 31.0 to 38.1%) of CKD patients showed signs of frailty, and 39.4% (95% CI 35.4 to 43.5%) had prefrail symptoms. Compared to non-frail patients, the risk of mortality was increased by 94.1% (95% CI 1.586 to 2.375) in frail patients and 34.5% (95% CI 1.231 to 1.469) in prefrail patients.
conclusionThe high prevalence of frailty and prefrail in adults with CKD and resulting in premature death emphasize the importance of measuring frailty, which provides important prognostic information and may provide opportunities for interventions to improve the prognosis of patients with CKD.
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