ReviewMayo Clinic proceedings2023
Functional Hypothalamic Amenorrhea: Recognition and Management of a Challenging Diagnosis.
Review in Mayo Clinic proceedings, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Stanozolol, an anabolic-androgenic steroid, modulates expression of receptors and disrupts uterine histoarchitecture in Mus musculus.Journal of molecular histology · 2026Article
- Review
- Variation in the diagnosis and management of functional hypothalamic amenorrhea across clinical specialties: A nationwide cross-sectional survey in China.The Journal of international medical research · 2026Article
- Benchmarking machine learning architectures for menstrual recovery prediction using physiologically informed synthetic wearable data.Scientific reports · 2026Article
- Association of sleep duration and quality with age at natural menopause: results from NHANES 2005-2018.BMC women's health · 2026Observational
- Longer duration of amenorrhea is associated with lower delay discounting and less hedonic eating in girls and young women with low-weight eating disorders.Scientific reports · 2026Article
- Circadian rhythm disruption impairs ovarian follicular development via NADEBioMedicine · 2026Article
- An Overview of the Impact of the Menstrual Cycle on Nutrient Metabolism: An Integrative Perspective.Nutrients · 2026Review
- Management of infertility in women with hypothalamic hypogonadotropic hypogonadism: an expert opinion.Reproductive biology and endocrinology : RB&E · 2026Review
- Secondary osteoporosis in a young woman: the hidden impact of functional hypothalamic amenorrhea.Journal of Yeungnam medical science · 2026Article
- Bone mineral density in women with functional hypothalamic amenorrhea compared to eumenorrheic controls and recently menopausal women.Frontiers in endocrinology · 2026Article
- Performance of large language models as an information resource on functional hypothalamic amenorrhea for patients and healthcare professionals.Frontiers in artificial intelligence · 2026Article
- Neurotrophic Control of Puberty: From Molecular Signaling to Disorders of Pubertal Timing.Current issues in molecular biology · 2025Review
- Changes in anti-mullerian hormone levels after recovery from functional hypothalamic amenorrhea: a retrospective cohort study about women with and without polycystic ovarian morphology.Reproductive biology and endocrinology : RB&E · 2025Article
- Metabolic and Endocrine Alterations in Underweight and Normal-Weight Women with Functional Hypothalamic Amenorrhea.Journal of clinical medicine · 2025Article
- The menstrual cycle is a vital sign across the lifespan.The Lancet. Obstetrics, gynaecology, & women's health · 2025Article
- Research recruitment strategies in the digital era: Opportunities and challenges of social media.Contemporary clinical trials · 2025Article
- Identification of genetic variants in patients with primary and secondary amenorrhea.Saudi medical journal · 2025Article
- Functional hypothalamic amenorrhea in adolescent athletes impairs bone accrual and increases fracture risk.Frontiers in endocrinology · 2025Review
- Effectiveness of Interventions to Improve Cardiovascular Perturbations in Women with Exercise-Associated Amenorrhea: A Systematic Review.Women's health reports (New Rochelle, N.Y.) · 2025Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Functional hypothalamic amenorrhea is responsible for approximately a third of the cases of secondary amenorrhea. The condition is a result of disturbances in gonadotropin-releasing hormone pulsatile secretion at the level of the hypothalamus, which in turn disrupts gonadotropin secretion. It is due to psychosocial stress, disordered eating, and/or excessive exercise. Often, however, it is a combination of more than one etiology, with a possible role for genetic or epigenetic predisposition. The dysfunctional gonadotropin-releasing hormone release leads to the cessation of ovarian function, resulting in amenorrhea, infertility, and a long-term impact on affected women's bone health, cardiovascular risk, cognition, and mental health. Functional hypothalamic amenorrhea is a diagnosis of exclusion, and treatment involves identifying and reversing the underlying cause(s). The aim of this concise review is to summarize the current knowledge of functional hypothalamic amenorrhea, review its pathophysiology and the adverse health consequences, and provide recommendations for diagnosis and management of this condition. Furthermore, this review will emphasize the gaps in research on this common condition impacting women of reproductive age all over the world.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.