Evidence map›Paper›PMID 37660963›Full record

ArticleAmerican journal of ophthalmology2024

Risk of Stroke, Myocardial Infarction, Deep Vein Thrombosis, Pulmonary Embolism, and Death After Retinal Vein Occlusion.

Karen M Wai, Cassie A Ludwig, Euna Koo, Ravi Parikh, Prithvi Mruthyunjaya, Ehsan Rahimy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Karen M WaiFrom Byers Eye Institute (K.M.W., C.A.L., E.K., P.M., E.R.), Horngren Family Vitreoretinal Center, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Cassie A LudwigFrom Byers Eye Institute (K.M.W., C.A.L., E.K., P.M., E.R.), Horngren Family Vitreoretinal Center, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Euna KooFrom Byers Eye Institute (K.M.W., C.A.L., E.K., P.M., E.R.), Horngren Family Vitreoretinal Center, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Ravi ParikhManhattan Retina and Eye Consultants (R.P.), New York, New York, USA; New York University Langone Health (R.P.), New York, New York, USA.
Prithvi MruthyunjayaFrom Byers Eye Institute (K.M.W., C.A.L., E.K., P.M., E.R.), Horngren Family Vitreoretinal Center, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Ehsan RahimyFrom Byers Eye Institute (K.M.W., C.A.L., E.K., P.M., E.R.), Horngren Family Vitreoretinal Center, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA; Department of Ophthalmology, Palo Alto Medical Foundation, Palo Alto, California, USA. Electronic address: erahimy@gmail.com.
Smith-Kettlewell Eye Research Institute · USManhattan Eye, Ear and Throat Hospital · USPalo Alto University · US

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Yang Hu · 2017 to 2026
$8.0M
Stanford K12 Clinician-Scientist Career Development ProgramK12EY033745 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2022 to 2026
$2.6M
NEI NIH HHS K12 EY033745NEI NIH HHS P30 EY026877
6 · The paper itself

Abstract

purposeTo examine rates of stroke, myocardial infarction (MI), deep vein thrombosis (DVT), pulmonary embolism (PE), and death in patients after retinal vein occlusion (RVO) compared to controls.

designRetrospective cohort study.

methodsAn aggregated electronic health records research network, TriNetX, was used to identify patients with diagnosis of RVO and a control group of patients with cataract. Patients were excluded if they had history of stroke, MI, DVT, or PE within 2 years of diagnosis of RVO or cataract. Propensity score matching was performed to control for baseline demographics and medical comorbidities. Main outcomes included relative risk (RR) of death, stroke, MI, DVT, and PE after RVO compared to those in matched controls.

resultsA total of 45,304 patients were included in each cohort. There was elevated risk of death in the RVO cohort compared to the control cohort at 1 year (RR = 1.30, P < .01), 5 years (RR = 1.22, P < .01), and 10 years (RR = 1.08, P < .01). There was elevated risk of stroke at 1 year (RR = 1.61, P < .01), 5 years (RR = 1.31, P < .01), and 10 years (RR = 1.18, P < .01). There was elevated risk of MI at 1 year (RR = 1.26, P < .01) and 5 years (RR = 1.13, P < .01), but not at 10 years (RR = 1.06, P = .12). There was mildly elevated risk of DVT at 1 year (RR = 1.65, P < .01) but not at 5 years (RR = 0.94, P = .94) or 10 years (RR = 1.05, P = .37). There was no elevated risk of PE at 1 year (RR = 0.98, P = 0.80), 5 years (RR = 0.95, P = .42), or 10 years (RR = 0.85, P =.40).

conclusionsThere is an increased rate of death, stroke, and MI after RVO compared to those in matched controls. We emphasize the need for long-term systemic evaluation after RVO.

Indexed as

CataractMyocardial InfarctionPulmonary EmbolismRetinal Vein OcclusionStrokeHumansRetrospective StudiesRisk Factors

Identifiers

PMID37660963
PMCPMC13318398
OpenAlexW4386380258

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.