Evidence map›Paper›PMID 37660744›Full record

Trial reportClinical immunology (Orlando, Fla.)2023

Systems analysis reveals differential expression of endocervical genes in African women randomized to DMPA-IM, LNG implant or cu-IUD.

Prachi Mehrotra Gupta, Christina Balle, Gregory K Tharp, Sydney A Nelson, Melanie A Gasper, Bryan Brown, Arghavan Alisoltani, Maricianah Onono, Thesla Palanee-Phillips, Gonsagrie Nair and 7 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical immunology (Orlando, Fla.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 3 countries.

Prachi Mehrotra GuptaEmory National Primate Research Center (ENPRC) Genomics Core Laboratory, Division of Microbiology & Immunology, Emory University, Atlanta, GA, USA.
Christina BalleDepartment of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa.
Gregory K TharpEmory National Primate Research Center (ENPRC) Genomics Core Laboratory, Division of Microbiology & Immunology, Emory University, Atlanta, GA, USA.
Sydney A NelsonEmory National Primate Research Center (ENPRC) Genomics Core Laboratory, Division of Microbiology & Immunology, Emory University, Atlanta, GA, USA.
Melanie A GasperSeattle Children's Research Institute, Seattle, WA, USA.
Bryan BrownSeattle Children's Research Institute, Seattle, WA, USA; Department of Pediatrics, University of Washington, Seattle, WA, USA.
Arghavan AlisoltaniDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Maricianah OnonoKenya Medical Research Institute, Kisumu, Kenya.
Thesla Palanee-PhillipsWits RHI, University of the Witwatersrand, Faculty of Health Sciences, School of Public Health, Johannesburg, South Africa; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Gonsagrie NairDesmond Tutu HIV Centre, Cape Town, South Africa.
Hosseana AyeleDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Laura Noel-RomasDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Jo-Ann S PassmoreDepartment of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; National Health Laboratory Service, Cape Town, South Africa; CAPRISA DSI-NRF Centre of Excellence in HIV Prevention, University of Cape Town, South Africa.
Adam D BurgenerDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Renee HeffronDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA; Department of Global Health, University of Washington, Seattle, WA, USA.
Heather B JaspanDepartment of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Seattle Children's Research Institute, Seattle, WA, USA; Department of Pediatrics, University of Washington, Seattle, WA, USA; Department of Global Health, University of Washington, Seattle, WA, USA.
Steven E BosingerEmory University School of Medicine, Department of Pathology & Laboratory Medicine, GA, USA; Emory Vaccine Center, Emory University, GA, USA. Electronic address: steven.bosinger@emory.edu.
Emory University · USCase Western Reserve University · USUniversity of Cape Town · ZAUniversity of Washington · USDesmond Tutu HIV Foundation · ZAKenya Medical Research Institute · KENational Health Laboratory Service · ZANorthwestern University · USSeattle Children's Hospital · USUniversity School · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Medical Scientist Training ProgramT32GM142617 · NIGMS · EMORY UNIVERSITY · PI Jason Yustein · 2022 to 2026
$7.0M
Effects of Hormonal Contraceptives on Genital Immunity and HIV SusceptibilityR01HD089831 · NICHD · UNIVERSITY OF WASHINGTON · PI HEFFRON, RENEE A., JASPAN, HEATHER BERYL · 2016 to 2020
$3.0M
Illumina NovaSeq 6000 High Throughput DNA Sequencer for Emory UniversityS10OD026799 · OD · EMORY UNIVERSITY · PI BOSINGER, STEVEN EDWARD · 2019 to 2019
$985k
NICHD NIH HHS R01 HD089831NIGMS NIH HHS T32 GM142617NIH HHS P51 OD011132NIH HHS S10 OD026799
6 · The paper itself

Abstract

Although effective contraceptives are crucial for preventing unintended pregnancies, evidence suggests that their use may perturb the female genital tract (FGT). A comparative analysis of the effects of the most common contraceptives on the FGT have not been evaluated in a randomized clinical trial setting. Here, we evaluated the effect of three long-acting contraceptive methods: depot medroxyprogesterone acetate(DMPA-IM), levonorgestrel(LNG) implant, and a copper intrauterine device (Cu-IUD), on the endocervical host transcriptome in 188 women from the Evidence for Contraceptive Options and HIV Outcomes Trial (ECHO) trial. Cu-IUD usage showed the most extensive transcriptomic changes, and was associated with inflammatory and anti-viral host responses. DMPA-IM usage was enriched for pathways associated with T cell responses. LNG implant had the mildest effect on endocervical gene expression, and was associated with growth factor signaling. These data provide a mechanistic basis for the diverse influence that varying contraceptives have on the FGT.

Indexed as

CopperIntrauterine Devices, CopperContraceptive AgentsFemaleHumansLevonorgestrelPregnancySystems AnalysisContraceptive AgentsCopperLevonorgestrelContraceptionFemale genital tractMucosaRandomized clinical trialReproductive healthTranscriptome

Identifiers

PMID37660744
PMCPMC10570927
OpenAlexW4386401938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.