Evidence map›Paper›PMID 37660542›Full record

ArticleParkinsonism & related disorders2023

Weight and survival after deep brain stimulation for Parkinson's disease.

Robert S Eisinger, Michael S Okun, Stephanie Cernera, Jackson Cagle, Matthew Beke, Adolfo Ramirez-Zamora, B Hope Kim, Daniel A N Barbosa, Liming Qiu, Pavan Vaswani and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. When the Scale Drops: Pathways to Weight Loss in Parkinson's Disease and Future Directions.Movement disorders : official journal of the Movement Disorder Society · 2026
    Review
  6. Vital nutrition: enhancing health in advanced Parkinson's disease with device-aided therapies.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Robert S EisingerDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, USA; Department of Neurology, Hospital of the University of Pennsylvania, USA. Electronic address: eisi@upenn.edu.
Michael S OkunDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, USA; Department of Neurosurgery, Norman Fixel Institute for Neurological Diseases, University of Florida, USA.
Stephanie CerneraDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, USA; Department of Neurosurgery, University of California, San Francisco, USA.
Jackson CagleDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, USA.
Matthew BekeDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, USA; Food Science and Human Nutrition Department, University of Florida, USA.
Adolfo Ramirez-ZamoraDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, USA.
B Hope KimDepartment of Neurology, Hospital of the University of Pennsylvania, USA.
Daniel A N BarbosaDepartment of Neurosurgery, Hospital of the University of Pennsylvania, USA.
Liming QiuDepartment of Neurosurgery, Hospital of the University of Pennsylvania, USA.
Pavan VaswaniDepartment of Neurology, Hospital of the University of Pennsylvania, USA.
Whitley W AamodtDepartment of Neurology, Hospital of the University of Pennsylvania, USA.
Casey H HalpernDepartment of Neurosurgery, Hospital of the University of Pennsylvania, USA; Department of Surgery, Corporal Michael J. Crescenz Veterans Affairs Medical Center, PA, Philadelphia, USA.
Kelly D FooteDepartment of Neurosurgery, Norman Fixel Institute for Neurological Diseases, University of Florida, USA.
Aysegul GunduzDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, USA; Department of Biomedical Engineering, University of Florida, USA.
Leonardo AlmeidaDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, USA; Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
Hospital of the University of Pennsylvania · USUniversity of Florida · USUniversity of California, San Francisco · USUniversity of Minnesota · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
Interdisciplinary Training in Movement Disorders and NeurorestorationT32NS082168 · NINDS · UNIVERSITY OF FLORIDA · PI Melissa Jo Armstrong, David E Vaillancourt · 2015 to 2026
$2.8M
Local field potentials reveal reward processing and impulse control disorders in Parkinson’s diseaseF30NS111841 · NINDS · UNIVERSITY OF FLORIDA · PI EISINGER, ROBERT STEPHEN · 2019 to 2022
$124k
NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR001427NINDS NIH HHS F30 NS111841NINDS NIH HHS T32 NS082168
6 · The paper itself

Abstract

backgroundWeight loss in Parkinson's disease (PD) is common and associated with increased mortality. The clinical significance of weight changes following deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) is unclear.

objectivesTo address (1) whether PD patients exhibit progressive weight loss, (2) whether staged DBS surgery is associated with weight changes, and (3) whether survival after DBS correlates with post-DBS weight.

methodsThis is a single-center, longitudinal, retrospective cohort study of 1625 PD patients. We examined trends in weight over time and the relationship between weight and years survival after DBS using regression and mixed model analyses.

resultsThere was a decline in body weight predating motor symptom onset (n = 756, 0.70 ± 0.03% decrease per year, p < 0.001). Weight decline accelerated in the decade preceding death (n = 456, 2.18 ± 0.31% decrease per year, p < 0.001). DBS patients showed a weight increase of 2.0 ± 0.33% at 1 year following the first DBS lead implant (n = 455) and 2.68 ± 1.1% at 3 years if a contralateral DBS lead was placed (n = 249). The bilateral STN DBS group gained the most weight after surgery during 6 years of follow up (vs bilateral GPi, 3.03 ± 0.45% vs 1.89 ± 0.31%, p < 0.01). An analysis of the DBS cohort with date of death available (n = 72) revealed that post-DBS weight (0-12 months after the first or 0-36 months after the second surgery) was positively associated with survival (R DISCUSSION: Though PD is associated with significant weight loss, DBS patients gained weight following surgery. Higher post-operative weight was associated with increased survival. These results should be replicated in other cohorts.

Indexed as

Deep Brain StimulationParkinson DiseaseGlobus PallidusHumansRetrospective StudiesTreatment OutcomeWeight LossDeep brain stimulationGlobus pallidus internusParkinson's diseaseSubthalamic nucleusSurvivalWeight

Identifiers

PMID37660542
PMCPMC10664863
OpenAlexW4385979798

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.