Evidence map›Paper›PMID 37660504›Full record

ArticlePlacenta2023

Detection of heat-stable antibacterial activity in cotyledonary and discoid placentas.

Logan D Stacey, Jonathan M Gubbrud, Alek C Keegan, Kelly R Kleekamp, Meghan A Kuntz, Matthew J Osmanski, Joshua J Schumacher, Jennifer A A Gubbels, Paul G Egland

Abstract read
In one paragraph

Article in Placenta, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Logan D StaceyDepartment of Biology, Augustana University, Sioux Falls, SD, 57197, USA.
Jonathan M GubbrudDepartment of Biology, Augustana University, Sioux Falls, SD, 57197, USA.
Alek C KeeganDepartment of Biology, Augustana University, Sioux Falls, SD, 57197, USA.
Kelly R KleekampDepartment of Biology, Augustana University, Sioux Falls, SD, 57197, USA.
Meghan A KuntzDepartment of Biology, Augustana University, Sioux Falls, SD, 57197, USA.
Matthew J OsmanskiDepartment of Biology, Augustana University, Sioux Falls, SD, 57197, USA.
Joshua J SchumacherDepartment of Biology, Augustana University, Sioux Falls, SD, 57197, USA.
Jennifer A A GubbelsDepartment of Biology, Augustana University, Sioux Falls, SD, 57197, USA.
Paul G EglandDepartment of Biology, Augustana University, Sioux Falls, SD, 57197, USA. Electronic address: paul.egland@augie.edu.

Funding

Wichozani-A Healthy Lifestyle for Rural American Indian Youth through Cultural and Physical Activities: A Community-Based Participatory Research StudyP20GM103443 · NIGMS · UNIVERSITY OF SOUTH DAKOTA · PI Ryan Michael Johnson · 2012 to 2026
$58.1M
NIGMS NIH HHS P20 GM103443
6 · The paper itself

Abstract

The placenta serves in immunological defense of the fetus, providing proteins essential for innate immunity. Maternal and fetal portions of two mammalian placenta types, discoid, and cotyledonary, were separated and analyzed for antibacterial activity using a culture-independent method. Antibacterial activity was detected in both maternal and fetal portions of all placenta types tested. Protease resistance and increased activity after boiling suggests that the factor is activated upon release from a larger molecule. Identification of this factor and the mechanism of activation will lead to a better understanding of the innate immune function provided by the placenta.

Indexed as

Hot TemperaturePlacentaAnimalsAnti-Bacterial AgentsFemaleHumansPregnancyAnti-Bacterial AgentsAntibacterialInnate immunityNatural antimicrobialsPlacenta

Identifiers

PMID37660504
PMCPMC10591983

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.