ArticleClinical epigenetics2023
Evaluation of pediatric epigenetic clocks across multiple tissues.
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Article in Clinical epigenetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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27citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Pooled it
- An epigenome-wide study of a needs-based family intervention for offspring of trauma-exposed mothers in Kosovo.Brain and behavior · 2024Trial
- Placental Pathophysiology and Developmental Programming of Adult Cardiometabolic Risk: A Narrative Review of Pregnancy Exposures.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- An epigenetic framework for understanding contextual influences on neural and socio-emotional development: Narrative review and case-study of the oxytocin receptor.Developmental cognitive neuroscience · 2026Review
- Longitudinal changes in epigenetic age acceleration prior to type 1 diabetes onset in the Diabetes Autoimmunity Study in the Young (DAISY).BMJ open diabetes research & care · 2026Article
- Community threat, positive parenting, and accelerated epigenetic aging: Longitudinal links from childhood to adolescence.Child development · 2026Article
- EpigeneticAgePipeline: An R Package for Comprehensive Assessment of Epigenetic Age Metrics From Methylation Microarrays.Bioinformatics and biology insights · 2026Article
- Analysis of prenatal medication use and placental epigenetic gestational age in extremely low gestational age newborns (ELGANs) highlight relationships to aspirin use during pregnancy.Clinical epigenetics · 2025Article
- Blood methylome signatures in children exposed to maternal type 1 diabetes are linked to protection against islet autoimmunity.Nature metabolism · 2025Article
- Prenatal organophosphate ester exposure and epigenetic changes at birth: a characterization of the methylome in the ECHO cohort.Environment international · 2025Article
- The Impact of Early Life Adversity on Peripubertal Accelerated Epigenetic Aging and Psychopathology.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Article
- Influence of race, ethnicity, and sex on the performance of epigenetic predictors of phenotypic traits.Clinical epigenetics · 2025Article
- Sex-specific effects of in utero exposure to per- and polyfluoroalkyl substances on placental development.Environmental research · 2025Article
- Cross-tissue comparison of epigenetic aging clocks in humans.Aging cell · 2025Article
- Decoding bronchopulmonary dysplasia in premature infants through an epigenetic lens.Frontiers in medicine · 2025Review
- Depression, Subjective Health, Obesity, and Multimorbidity are Associated with Epigenetic Age Acceleration.Journal of biomedical and life sciences · 2025Article
- Associations of epigenetic age acceleration at birth and age 12 years with adolescent cardiometabolic risk: the HOME study.Clinical epigenetics · 2024Article
- Sex-Specific Associations between Prenatal Exposure to Bisphenols and Phthalates and Infant Epigenetic Age Acceleration.Epigenomes · 2024Article
- Prenatal stress and gestational epigenetic age: No evidence of associations based on a large prospective multi-cohort study.Research square · 2024Article
- Individual longitudinal changes in DNA-methylome identify signatures of early-life adversity and correlate with later outcome.Neurobiology of stress · 2024Article
Corrections and comments
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Authors and funding
29 authors at 16 institutions in 1 country.
Fang FangGenOmics and Translational Research Center, RTI International, Research Triangle Park, 3040 East Cornwallis Road, Durham, NC, 27709-2194, USA. ffang@rti.org.
Linran ZhouGenOmics and Translational Research Center, RTI International, Research Triangle Park, 3040 East Cornwallis Road, Durham, NC, 27709-2194, USA.
Wei PerngDepartment of Epidemiology, Colorado School of Public Health, Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Carmen J MarsitGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Anna K KnightDepartment of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA.
Andres CardenasDepartment of Epidemiology and Population Health, Stanford School of Medicine, Stanford, CA, USA.
Max T AungDivision of Environmental Health, Department of Population and Populace Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Marie-France HivertDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Izzuddin M ArisDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Jaclyn M GoodrichDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA.
Alicia K SmithDepartment of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA.
Abigail GaylordDepartment of Population Health, New York University School of Medicine, New York, NY, USA.
Rebecca C FryDepartment of Environmental Sciences and Engineering, UNC-Chapel Hill, Chapel Hill, NC, USA.
Emily OkenDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
George O'ConnorPulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Douglas M RudenDepartment of Obstetrics and Gynecology, Institute of Environmental Health Sciences, Wayne State University, Detroit, MI, USA.
Leonardo TrasandeDepartment of Population Health, New York University School of Medicine, New York, NY, USA.
Julie B HerbstmanMailman School of Public Health, Columbia University, New York, NY, USA.
Carlos A CamargoDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Nicole R BushDepartment of Psychiatry and Behavioral Sciences, Department of Pediatrics, University of California, San Francisco, CA, USA.
Anne L DunlopDepartment of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA.
Dana M DabeleaDepartment of Epidemiology, Colorado School of Public Health, Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Margaret R KaragasDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Carrie V BretonDivision of Environmental Health, Department of Population and Populace Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Carole OberDepartment of Human Genetics, University of Chicago, Chicago, IL, USA.
Todd M EversonGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Grier P PageGenOmics and Translational Research Center, RTI International, Research Triangle Park, 3040 East Cornwallis Road, Durham, NC, 27709-2194, USA.
Christine Ladd-AcostaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
program collaborators for Environmental influences on Child Health Outcomes
Johns Hopkins University · USEmory University · USDartmouth College · USHarvard University · USRTI International · USUniversity of North Carolina at Chapel Hill · USColorado School of Public Health · USUniversity of California, San Francisco · USUniversity of Chicago · USNew York University · USUniversity of Southern California · USBoston University · USColumbia University · USStanford Medicine · USUniversity of Michigan · USWayne State University · US
Funding
Project-005U2COD023375 · OD · DUKE UNIVERSITY · PI Phillip Brian Smith · 2016 to 2026
$215.9MECHODAC (Environmental Influences on Child Health Outcomes Data Analysis Center)U24OD023382 · OD · JOHNS HOPKINS UNIVERSITY · PI Diane J Catellier, LISA P JACOBSON · 2016 to 2026
$148.4MInner City Asthma consortium 3 (ICAC3)UM1AI114271 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E., JACKSON, DANIEL J · 2014 to 2021
$79.4MWisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-UpUH3OD023282 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern · 2018 to 2026
$64.8MThe NYU Children’s Health & Environment Study: an ECHO CohortUH3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Akhgar Ghassabian, Leonardo Trasande · 2018 to 2026
$59.5MA prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort StudyUH3OD023275 · OD · DARTMOUTH COLLEGE · PI MARGARET Rita KARAGAS, Juliette Madan · 2018 to 2026
$44.3MThe ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child HealthU24OD023319 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Courtney K Blackwell, RICHARD GERSHON · 2016 to 2026
$43.7MChildhood Asthma in Urban Settings Leadership Center Administrative Supplement for URECA Yr4UM1AI160040 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern, DANIEL J JACKSON · 2021 to 2026
$41.1MPrenatal and Early Childhood Pathways To Health: An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MLifecourse Approach to Developmental Repercussions of Environmental Agents on Metabolic and Respiratory Health (LA DREAMERs)UH3OD023287 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M, BRETON, CARRIE VAN DOREN · 2018 to 2022
$28.4MUnderstanding Breastfeeding Practices Among ECHO Cohort Participants Before and During/After the COVID-19 PandemicUH3OD023285 · OD · MICHIGAN STATE UNIVERSITY · PI Charles James Barone, MICHAEL R. ELLIOTT · 2018 to 2026
$24.5MNCATS NIH HHS KL2 TR002534NIAID NIH HHS UM1 AI114271NIAID NIH HHS UM1 AI160040NICHD NIH HHS R01 HD034568NICHD NIH HHS R01 HD072267NICHD NIH HHS R01 HD084515NIDDK NIH HHS R01 DK076648NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30 ES017885NIEHS NIH HHS P30 ES020957NIEHS NIH HHS P42 ES030991NIH HHS S10 OD025170NIH HHS U24 OD023319NIH HHS U24 OD023382NIH HHS U2C OD023375NIH HHS UG3 OD023282NIH HHS UG3 OD023285NIH HHS UG3 OD023347NIH HHS UG3 OD023348NIH HHS UG3 OD035521NIH HHS UH3 OD023248NIH HHS UH3 OD023253NIH HHS UH3 OD023271NIH HHS UH3 OD023275NIH HHS UH3 OD023282NIH HHS UH3 OD023285NIH HHS UH3 OD023286NIH HHS UH3 OD023287NIH HHS UH3 OD023288NIH HHS UH3 OD023290NIH HHS UH3 OD023305NIH HHS UH3 OD023318NIH HHS UH3 OD023342NIH HHS UH3 OD023347NIH HHS UH3 OD023348NIH HHS UH3 OD035521NIMHD NIH HHS R01 MD009064
Abstract
backgroundEpigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination.
resultsOur study used data from seven tissue types on three DNA methylation profiling microarrays and found that the Knight and Bohlin clocks performed similarly for blood cells, while the Lee clock was superior for placental samples. The pediatric-buccal-epigenetic clock performed the best for pediatric buccal samples, while the Horvath clock is recommended for children's blood cell samples. The NeoAge clock stands out for its unique ability to predict post-menstrual age with high correlation with the observed age in infant buccal cell samples.
conclusionsOur findings provide valuable guidance for future research and development of epigenetic clocks in pediatric samples, enabling more accurate assessments of biological age.
Indexed as
DNA MethylationPlacentaChildEpigenesis, GeneticEpigenomicsFemaleHumansInfantPregnancyDNA methylationEarly childhood chronological ageEpigenetic clockGestational age
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