Evidence map›Paper›PMID 37659984›Full record

ArticleMolecular biology reports2023

Role of some inflammasomes in rheumatoid arthritis patients in Egypt.

Reham Ibrahem, Mervat A Raghip, Mamdouh M Abdelwahed, Noha S Amin, Esam M Abualfadl, Nancy G F M Waly

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Reham IbrahemMicrobiology and Immunology Department, Faculty of Pharmacy, Minia University, Minya, Egypt.
Mervat A RaghipMicrobiology and Immunology Department, Faculty of Pharmacy, Sohag University, Sohag, Egypt.
Mamdouh M AbdelwahedMedical Microbiology and Immunology Department, Faculty of Medicine, Sohag University, Sohag, Egypt.
Noha S AminMedical Microbiology and Immunology Department, Faculty of Medicine, Sohag University, Sohag, Egypt.
Esam M AbualfadlRheumatology and Rehabilitation Department, Faculty of Medicine, Sohag University, Sohag, Egypt.
Nancy G F M WalyMicrobiology and Immunology Department, Faculty of Pharmacy, Minia University, Minya, Egypt. nancy.gamil1@mu.edu.eg.ORCID http://orcid.org/0000-0002-6878-0678
Sohag University · EGMinia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study aims to demonstrate the role of some inflammasomes genes: NLRC4 (the NLR family, CARD domain-containing protein 4), NLRP1 (NLR family, pyrin domain-containing 1), ASC (Apoptosis-associated speck-like protein containing a CARD), and CASPASE-1 in the pathogenesis of Rheumatoid arthritis (RA) in Egyptian population. MAIN

methodsThe expression level of NLRC4, NLRP1, ASC, and CASPASE-1 within PBMCs isolated from all RA subjects by quantitative real-time PCR. GAPDH gene was used as a reference gene. Measurement of serum level of IL-1β and IL-18 was performed using ELISA. KEY

findingsResults showed dysregulated inflammasomes expression that may participate in the pathogenesis of the inflammatory process of the disease. SIGNIFICANCE: Understanding the role of inflammasomes in RA pathogenesis helps in finding promising therapy for the treatment and management of this disease.

Indexed as

Arthritis, RheumatoidInflammasomesCARD Signaling Adaptor ProteinsCaspase 1EgyptHumansInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinCARD Signaling Adaptor ProteinsCaspase 1InflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinASCCASPASE-1InflammasomesNLRC4NLRP1Rheumatoid arthritis

Identifiers

PMID37659984
PMCPMC10635908
OpenAlexW4386388014

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.