Evidence map›Paper›PMID 37659980›Full record

ArticleWorld journal of urology2023

Tomato lipidic extract plus selenium decrease prostatic hyperplasia, dihydrotestosterone and androgen receptor expression versus finasteride in rats.

David Julian Arias-Chávez, Patrick Mailloux-Salinas, Jessica Ledesma-Aparicio, Elihu Campos-Pérez, Omar Noel Medina-Campos, José Pedraza-Chaverri, Guadalupe Bravo

Open access · hybridAbstract read
In one paragraph

Article in World journal of urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Role of Vitamin B₆ in Testosterone Synthesis.The world journal of men's health · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

David Julian Arias-ChávezDepartamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del IPN, Sede Sur, Ciudad de México, Mexico.
Patrick Mailloux-SalinasDepartamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del IPN, Sede Sur, Ciudad de México, Mexico.
Jessica Ledesma-AparicioDepartamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del IPN, Sede Sur, Ciudad de México, Mexico.
Elihu Campos-PérezDepartamento de Patología, Hospital General Dra Matilde Petra Montoya Lafragua, ISSSTE, Ciudad de México, Mexico.
Omar Noel Medina-CamposLaboratorio F-315, Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
José Pedraza-ChaverriLaboratorio F-315, Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Guadalupe BravoDepartamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del IPN, Sede Sur, Ciudad de México, Mexico. gubravo@cinvestav.mx.ORCID http://orcid.org/0000-0002-2730-7761
Instituto Politécnico Nacional · MXUniversidad Nacional Autónoma de México · MXUniversidad Autónoma de la Ciudad de México · MX

Funding

Consejo Nacional de Ciencia y Tecnología 754007
6 · The paper itself

Abstract

purposeEvaluate the therapeutic effect of a tomato lipidic extract (STE) in combination with selenium (Se) on rats with prostatic hyperplasia (PH) and to observe its possible mechanisms of action and synergism versus finasteride. MATERIALS AND

methods54 male Wistar rats of nine weeks old were divided in Control (C), PH, Finasteride (F), STE, Se, F + STE, F + Se, STE + Se and F + STE + Se with testosterone enanthate (except C). After 4 weeks of treatment administration, prostate weight, bladder weight, diuresis, prooxidant and antioxidant activity, dihydrotestosterone (DHT), androgen receptor (AR) expression and anatomopathological analysis were determined.

resultsSTE + Se decreased prostate weight 53.8% versus 28% in F group, also STE + Se decreased significatively glandular hyperplasia, prooxidant activity, DHT and AR expression and increased diuresis and antioxidant activity versus finasteride which increased MDA in prostate.

conclusionsThese results demonstrate a greater therapeutic and beneficial effect of tomato lipidic extract in combination with Se in young rats with PH with respect to finasteride without increase prooxidant activity.

Indexed as

Prostatic HyperplasiaSeleniumSolanum lycopersicumAndrogensAnimalsAntioxidantsDihydrotestosteroneFinasterideMaleRatsRats, WistarReceptors, AndrogenTestosteroneAndrogensAntioxidantsDihydrotestosteroneFinasterideReceptors, AndrogenSeleniumTestosteroneAndrogen receptorDihydrotestosteroneFinasterideProstatic hyperplasiaSeleniumTomato

Identifiers

PMID37659980
PMCPMC10582118
OpenAlexW4386387095

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.