Evidence map›Paper›PMID 37659676›Full record

ArticleGastroenterology2023

Genetic Defect in Submucosal Gland-Associated Caveolin-3: A New Paradigm in Esophageal Adenocarcinoma Risk.

Katherine S Garman, Biswa P D Purkayastha, Joyce A Hogue, Ryan Fecteau, BETRNet CONSORTIUM, Kishore Guda, Amitabh Chak

Open access · bronzeAbstract read
In one paragraph

Article in Gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Pathogenesis of Barrett's Esophagus: Evolving and Emerging Mechanisms.Gastrointestinal endoscopy clinics of North America · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Katherine S GarmanDivision of Gastroenterology, Duke Molecular Physiology Institute, and, Department of Medicine, Duke University, Durham, North Carolina.
Biswa P D PurkayasthaHuman Genetics, Allied Health Sciences, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India.
Joyce A HogueDivision of Gastroenterology, Duke Molecular Physiology Institute, and, Department of Medicine, Duke University, Durham, North Carolina.
Ryan FecteauDepartment of Radiation Oncology, Duke University Medical Center, Durham, North Carolina.
BETRNet CONSORTIUM
Kishore GudaCase Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio; Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, Ohio; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio. Electronic address: kkg5@case.edu.
Amitabh ChakCase Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio; Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, Ohio; Division of Gastroenterology and Hepatology, Case Western Reserve University School of Medicine, Cleveland, Ohio. Electronic address: axc22@case.edu.
University School · USDuke University · USDatta Meghe Institute of Higher Education and Research · INDuke Medical Center · USHospital of the University of Pennsylvania · USNorth Carolina State University · US

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI JOHN N. NORTON · 1985 to 2026
$174.8M
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
Targeting 15-PGDH in Colon Cancer Prognosis, Prediction, Treatment and PreventionP50CA150964 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MARKOWITZ, SANFORD D. · 2011 to 2022
$24.6M
The Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI AMITABH CHAK · 2015 to 2026
$15.6M
Whole Exome Approaches for Esophageal Adenocarcinoma Susceptibility GenesU54CA163060 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI CHAK, AMITABH, GUDA, KISHORE · 2011 to 2022
$14.0M
Pathways of Injury and Repair in Barrett's CarcinogenesisP01CA269019 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Katherine Garman · 2023 to 2026
$11.1M
Identify and validate novel epigenetic molecular markers for colorectal neoplasmU01CA152756 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GRADY, WILLIAM MALLORY, GUDA, KISHORE · 2010 to 2021
$6.7M
The role of gastrin in esophageal submucosal gland acinar ductal metaplasiaR01DK118022 · NIDDK · DUKE UNIVERSITY · PI GARMAN, KATHERINE · 2018 to 2022
$2.3M
EPHA6 as a novel candidate driver gene in colon cancerR01CA204549 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI GUDA, KISHORE · 2016 to 2020
$1.8M
Submucosal esophageal structures as a progenitor niche for esophageal repairK08DK098528 · NIDDK · DUKE UNIVERSITY · PI GARMAN, KATHERINE · 2013 to 2017
$594k
NCI NIH HHS P01 CA269019NCI NIH HHS P30 CA014236NCI NIH HHS P50 CA150964NCI NIH HHS R01 CA204549NCI NIH HHS U01 CA152756NCI NIH HHS U54 CA163060NIDDK NIH HHS K08 DK098528NIDDK NIH HHS P30 DK034987NIDDK NIH HHS P30 DK097948NIDDK NIH HHS R01 DK118022
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdenocarcinomaCaveolin 3Esophageal NeoplasmsHumansCaveolin 3

Identifiers

PMID37659676
PMCPMC10872754
OpenAlexW4386319231

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.