ArticleNeuron2023
Differential cortical network engagement during states of un/consciousness in humans.
Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 38 citations in OpenAlex.
- Anesthesia unconsciousness recruits dynamic parabrachial activity within a distributed brain-wide ensemble.bioRxiv : the preprint server for biology · 2026Article
- Article
- Opposite network patterns of integration-segregation in psychedelic and sedated states of consciousness.Cell reports · 2026Article
- State-Dependent Modulation of a Theta-Responsive Subnetwork by High-Frequency Stimulation of the Ventral Striatum.Neuroscience bulletin · 2026Article
- Anti-Seizure Medications Alter Functional and Effective Connectivity as Measured With Intracranial Electroencephalography.Brain and behavior · 2026Article
- Esketamine Preserves Network Connectivity and Promotes Recovery in Consciousness Disorders.CNS neuroscience & therapeutics · 2026Article
- Age-Dependent Entropic Features During Propofol Anesthesia in Developing Brain.Anesthesia and analgesia · 2026Article
- Distinct origins of human low and high alpha rhythms revealed by simultaneous EEG-SEEG.Communications biology · 2026Article
- Atlas of intracranial electroencephalography complexity across cortical regions and global states of consciousness in the human brain.PNAS nexus · 2026Article
- Opposing Network Patterns of Integration-Segregation in Psychedelic and Sedated States of Consciousness.bioRxiv : the preprint server for biology · 2026Article
- Directed cortico-limbic dialogue in the human brain.Nature communications · 2026Article
- Dexmedetomidine produces more sleep-like brain activity compared with propofol in human participants.British journal of anaesthesia · 2026Article
- Wakefulness regulation of memory encoding and retrieval: structure and activity.National science review · 2026Review
- Illuminating consciousness.Frontiers in psychology · 2026Review
- Windows to Consciousness: The Role of Fronto-Parietal Connectivity in Anesthesia-Induced Unconsciousness.Current neuropharmacology · 2026Review
- The Modulatory Effects of Anesthetics and Analgesics on Neurophysiological Monitoring and Underlying Mechanisms.Current neuropharmacology · 2026Review
- A thalamic perspective of (un)consciousness in pharmacological and pathological states in humans.Brain communications · 2026Article
- Modulation of Auditory Novelty Processing by Dexmedetomidine and Natural Sleep: A Human Intracranial Electrophysiology Study.The European journal of neuroscience · 2025Article
- Convergent effects of different anesthetics on changes in phase alignment of cortical oscillations.Cell reports · 2025Article
- Neural models for detection and classification of brain states and transitions.Communications biology · 2025Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
What happens in the human brain when we are unconscious? Despite substantial work, we are still unsure which brain regions are involved and how they are impacted when consciousness is disrupted. Using intracranial recordings and direct electrical stimulation, we mapped global, network, and regional involvement during wake vs. arousable unconsciousness (sleep) vs. non-arousable unconsciousness (propofol-induced general anesthesia). Information integration and complex processing we`re reduced, while variability increased in any type of unconscious state. These changes were more pronounced during anesthesia than sleep and involved different cortical engagement. During sleep, changes were mostly uniformly distributed across the brain, whereas during anesthesia, the prefrontal cortex was the most disrupted, suggesting that the lack of arousability during anesthesia results not from just altered overall physiology but from a disconnection between the prefrontal and other brain areas. These findings provide direct evidence for different neural dynamics during loss of consciousness compared with loss of arousability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.