Evidence map›Paper›PMID 37659105›Full record

SynthesisJournal of the American Medical Informatics Association : JAMIA2023

Prediction models using artificial intelligence and longitudinal data from electronic health records: a systematic methodological review.

Lucía A Carrasco-Ribelles, José Llanes-Jurado, Carlos Gallego-Moll, Margarita Cabrera-Bean, Mònica Monteagudo-Zaragoza, Concepción Violán, Edurne Zabaleta-Del-Olmo

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of the American Medical Informatics Association : JAMIA, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  7. From patient notes to prognostication: The revolutionary potential of event-based foundation models in orthopaedics.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026
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  18. Developing and internally validating AI-based aging resilience biomarkers in non-human primates.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lucía A Carrasco-RibellesFundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol I Gurina (IDIAPJGol), Barcelona, 08007, Spain.ORCID 0000-0001-9263-1747
José Llanes-JuradoInstituto de Investigación e Innovación en Bioingeniería (i3B), Universitat Politècnica de València (UPV), València, 46022, Spain.
Carlos Gallego-MollFundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol I Gurina (IDIAPJGol), Barcelona, 08007, Spain.
Margarita Cabrera-BeanDepartment of Signal Theory and Communications, Universitat Politècnica de Catalunya (UPC), Barcelona, 08034, Spain.
Mònica Monteagudo-ZaragozaFundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol I Gurina (IDIAPJGol), Barcelona, 08007, Spain.
Concepción ViolánUnitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol I Gurina (IDIAPJGol), Mataró, 08303, Spain.
Edurne Zabaleta-Del-OlmoFundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol I Gurina (IDIAPJGol), Barcelona, 08007, Spain.

Funding

AGAUR 2021-SGR-01033Carlos III Institute of Health, Ministry of Economy and CompetitivenessEuropean Regional Development FundHealth Strategy Action 2013-2016PFIS FI20/00040Technical, Scientific and Innovation Research National Plan 2013-2016 PI19/00535
6 · The paper itself

Abstract

objectiveTo describe and appraise the use of artificial intelligence (AI) techniques that can cope with longitudinal data from electronic health records (EHRs) to predict health-related outcomes.

methodsThis review included studies in any language that: EHR was at least one of the data sources, collected longitudinal data, used an AI technique capable of handling longitudinal data, and predicted any health-related outcomes. We searched MEDLINE, Scopus, Web of Science, and IEEE Xplorer from inception to January 3, 2022. Information on the dataset, prediction task, data preprocessing, feature selection, method, validation, performance, and implementation was extracted and summarized using descriptive statistics. Risk of bias and completeness of reporting were assessed using a short form of PROBAST and TRIPOD, respectively.

resultsEighty-one studies were included. Follow-up time and number of registers per patient varied greatly, and most predicted disease development or next event based on diagnoses and drug treatments. Architectures generally were based on Recurrent Neural Networks-like layers, though in recent years combining different layers or transformers has become more popular. About half of the included studies performed hyperparameter tuning and used attention mechanisms. Most performed a single train-test partition and could not correctly assess the variability of the model's performance. Reporting quality was poor, and a third of the studies were at high risk of bias.

conclusionsAI models are increasingly using longitudinal data. However, the heterogeneity in reporting methodology and results, and the lack of public EHR datasets and code sharing, complicate the possibility of replication. REGISTRATION: PROSPERO database (CRD42022331388).

Indexed as

Artificial IntelligenceElectronic Health RecordsHumansartificial intelligencedeep learningelectronic health recordslongitudinal datapredictionsystematic review

Identifiers

PMID37659105
PMCPMC10654870

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.