ArticleAging clinical and experimental research2023
Handgrip strength asymmetry as a new biomarker for sarcopenia and individual sarcopenia signatures.
Article in Aging clinical and experimental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07414888 (Comparison of Dominant and Non-Dominant Side Muscle Strength Asymmetry in Sarcopenic and Non-Sarcopenic Older Adults), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Dominant and Non-Dominant Side Muscle Strength Asymmetry in Sarcopenic and Non-Sarcopenic Older Adults
Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Two-wave status patterns of handgrip strength asymmetry and low handgrip strength in relation to all-cause mortality in middle-aged and older Chinese adults.GeroScience · 2026Article
- Biomarkers of Sarcopenia: Current Status and Future Perspectives.Aging medicine (Milton (N.S.W)) · 2026Review
- The crossroads between osteosarcopenia and intrinsic capacity-a narrative review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Review
- The prevalence and influencing factors of dynapenia among middle-aged and elderly individuals with knee osteoarthritis: a cross-sectional analysis.BMC musculoskeletal disorders · 2026Article
- Posttraumatic Stress Disorder and Handgrip Strength Among World Trade Center Firefighters and Emergency Medical Responders.International journal of environmental research and public health · 2026Article
- Association of Triglyceride-Glucose Index and Its Related Parameters With Handgrip Strength Asymmetry.Journal of cachexia, sarcopenia and muscle · 2026Article
- Vitamin D and Sarcopenia: Implications for Muscle Health.Biomedicines · 2025Review
- Relationship of handgrip strength, asymmetries, and calf circumference with functional capacity in individuals with intellectual disabilities: an age group analysis.BMC sports science, medicine & rehabilitation · 2025Article
- Plasma brain-derived neurotrophic factor concentrations are elevated in community-dwelling adults with sarcopenia.Age and ageing · 2025Article
- A neural network approach to sarcopenia prediction based on bioelectrical impedance in community-dwelling older adults.PloS one · 2025Article
- Relationship of Handgrip Strength and Asymmetry with Walking Ability in Older Adults with Excess Adiposity.Advanced biology · 2024Article
- Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions.Biomedicines · 2024Review
- Plasma C-terminal agrin fragment concentrations across adulthood: Reference values and associations with skeletal muscle health.Journal of cachexia, sarcopenia and muscle · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough handgrip strength (HGS) asymmetry has clinical screening utility, its relevance to sarcopenia is unknown. This study examined the relationship between HGS asymmetry and sarcopenia signatures, and explored the relevance of circulating neural/neuromuscular markers.
methods9403 individuals aged 18-92 years participated in this study. Maximal HGS and skeletal muscle index (SMI) were determined using hand dynamometry and DXA. Sarcopenia was diagnosed upon the presence of low HGS and low SMI, according to cohort-specific thresholds. Plasma biomarkers were measured by ELISA in a sub-group of 269 participants aged 50-83 years. Asymmetry was determined as the highest recorded HGS divided by the highest recorded HGS of the opposite hand. Individuals with a ratio > 1.10 were classified as having asymmetrical HGS.
resultsSubjects with asymmetrical HGS had significantly lower SMI (7.67 kg/m DISCUSSION: Our findings demonstrate the utility of HGS asymmetry as a screening tool that may complement existing strategies seeking to combat sarcopenia. Biomarker analyses suggest that heightened denervation may be an important aetiological factor underpinning HGS asymmetry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.