Evidence map›Paper›PMID 37658900›Full record

ArticleEuropean radiology2024

Imaging features to distinguish posterior fossa ependymoma subgroups.

Thomas Leclerc, Raphael Levy, Arnault Tauziède-Espariat, Charles-Joris Roux, Kevin Beccaria, Thomas Blauwblomme, Stéphanie Puget, Jacques Grill, Christelle Dufour, Léa Guerrini-Rousseau and 9 more

Abstract read
PubMed Publisher
In one paragraph

Article in European radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Thomas LeclercPediatric Radiology Department, Assistance-Publique Hôpitaux de Paris (AP-HP), Hôpital Universitaire Necker-Enfants Malades, 149 Rue de Sèvres, 75015, Paris, France.
Raphael LevyPediatric Radiology Department, Assistance-Publique Hôpitaux de Paris (AP-HP), Hôpital Universitaire Necker-Enfants Malades, 149 Rue de Sèvres, 75015, Paris, France.
Arnault Tauziède-EspariatNeuropathology Department, GHU Paris, Université Paris Cité, Paris, France.
Charles-Joris RouxPediatric Radiology Department, Assistance-Publique Hôpitaux de Paris (AP-HP), Hôpital Universitaire Necker-Enfants Malades, 149 Rue de Sèvres, 75015, Paris, France.
Kevin BeccariaPediatric Neurosurgery Department, AP-HP, Hôpital Universitaire Necker-Enfants Malades, Paris, France.
Thomas BlauwblommePediatric Neurosurgery Department, AP-HP, Hôpital Universitaire Necker-Enfants Malades, Paris, France.
Stéphanie PugetPediatric Neurosurgery Department, AP-HP, Hôpital Universitaire Necker-Enfants Malades, Paris, France.
Jacques GrillDepartment of Pediatric and Adolescent Oncology, Gustave Roussy Institute, Villejuif, France.
Christelle DufourDepartment of Pediatric and Adolescent Oncology, Gustave Roussy Institute, Villejuif, France.
Léa Guerrini-RousseauDepartment of Pediatric and Adolescent Oncology, Gustave Roussy Institute, Villejuif, France.
Samuel AbbouDepartment of Pediatric and Adolescent Oncology, Gustave Roussy Institute, Villejuif, France.
Stéphanie BolleDepartment of Radiotherapy Oncology, Gustave Roussy, Villejuif, France.
Alexandre RouxNeurosurgery Department, GHU Paris, Université Paris Cité, Paris, France.
Johan PalludNeurosurgery Department, GHU Paris, Université Paris Cité, Paris, France.
Corentin ProvostNeuroradiology Department, GHU Paris, Université Paris Cité, Paris, France.
Catherine OppenheimNeuroradiology Department, GHU Paris, Université Paris Cité, Paris, France.
Pascale VarletNeuropathology Department, GHU Paris, Université Paris Cité, Paris, France.
Nathalie BoddaertPediatric Radiology Department, Assistance-Publique Hôpitaux de Paris (AP-HP), Hôpital Universitaire Necker-Enfants Malades, 149 Rue de Sèvres, 75015, Paris, France.
Volodia Dangouloff-RosPediatric Radiology Department, Assistance-Publique Hôpitaux de Paris (AP-HP), Hôpital Universitaire Necker-Enfants Malades, 149 Rue de Sèvres, 75015, Paris, France. volodia.dangouloff-ros@aphp.fr.ORCID http://orcid.org/0000-0003-1260-5886

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPosterior fossa ependymoma group A (EPN_PFA) and group B (EPN_PFB) can be distinguished by their DNA methylation and give rise to different prognoses. We compared the MRI characteristics of EPN_PFA and EPN_PFB at presentation.

methodsPreoperative imaging of 68 patients with posterior fossa ependymoma from two centers was reviewed by three independent readers, blinded for histomolecular grouping. Location, tumor extension, tumor volume, hydrocephalus, calcifications, tissue component, enhancement or diffusion signal, and histopathological data (cellular density, calcifications, necrosis, mitoses, vascularization, and microvascular proliferation) were compared between the groups. Categorical data were compared between groups using Fisher's exact tests, and quantitative data using Mann-Whitney tests. We performed a Benjamini-Hochberg correction of the p values to account for multiple tests.

resultsFifty-six patients were categorized as EPN_PFA and 12 as EPN_PFB, with median ages of 2 and 20 years, respectively (p = 0.0008). The median EPN_PFA tumoral volume was larger (57 vs 29 cm

conclusionMorphological characteristics from imaging differ between posterior fossa ependymoma subtypes and may help to distinguish them preoperatively. CLINICAL RELEVANCE STATEMENT: This study provides a tool to differentiate between group A and group B ependymomas, which will ultimately allow the therapeutic strategy to be adapted in the early stages of patient management. KEY POINTS: • Posterior fossa ependymoma subtypes often have different imaging characteristics. • Posterior fossa ependymomas group A are commonly median or lateral tissular calcified masses, with incomplete enhancement, affecting young children and responsible for pronounced hydrocephalus and invasion of the posterior fossa foramina. • Posterior fossa ependymomas group B are commonly median non-calcified masses of adolescents and adults, predominantly cystic, and minimally invasive, with total and homogeneous enhancement.

Indexed as

EpendymomaHydrocephalusAdolescentAdultChildChild, PreschoolHeadHumansMagnetic Resonance ImagingPrognosisYoung AdultBrain neoplasmsChildEpendymomaFourth ventricleMagnetic resonance imaging

Identifiers

PMID37658900

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.