SynthesisEuropean radiology2024
The diagnostic performance of salivary gland ultrasound elastography in Sjögren's syndrome and sicca symptoms: a systematic review and meta-analysis.
Synthesis in European radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Assessment of salivary gland involvement in primary Sjögren's syndrome using ultrasound viscoelasticity imaging.European radiology · 2026Article
- Vascular Endothelial Barrier in Salivary Glands: From Physiological Regulation to Pathological Impairment of Secretion.International journal of molecular sciences · 2026Review
- The diagnostic performance of salivary gland shear wave elastography to differentiate Sjögren disease from type 2 diabetes mellitus with sicca: a cross-sectional controlled study.BMC medical imaging · 2026Article
- Diagnostic performance of conventional ultrasound and shear wave elastography of the parotid glands in primary Sjögren's syndrome.BMC medical imaging · 2026Article
- Diagnostic Performance of Parotid Shear-Wave Elastography for Predicting Histopathological Positivity in Patients with Suspected Primary Sjögren's Syndrome.Diagnostics (Basel, Switzerland) · 2026Article
- The diagnostic value and clinical relevance of salivary gland ultrasound in patients with highly suspected Sjögren's Disease: a prospective monocentric study.Arthritis research & therapy · 2025Article
- Value of combined application of the OMERACT scoring system and shear wave elastography for primary Sjögren's syndrome.Clinical rheumatology · 2025Article
- Shear Wave Elastography for Parotid Glands: Quantitative Analysis of Shear Elastic Modulus in Relation to Age, Gender, and Internal Architecture in Patients with Oral Cancer.Journal of imaging · 2025Article
- Impact of disease duration on systemic clinical profile in Sjogren's syndrome.Arthritis research & therapy · 2025Article
- Multimodal Elastography of the Main Salivary Glands-A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Salivary gland ultrasound elastography requires interpretation of "normal".Laryngoscope investigative otolaryngology · 2024Article
- A comprehensive review of Sjögren's syndrome: Classification criteria, risk factors, and signaling pathways.Heliyon · 2024Review
- Performance of salivary glands ultrasonography, shear wave elastography and their combined use for the diagnosis of primary and secondary Sjögren's syndrome.Journal of applied clinical medical physics · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo systematically evaluate the diagnostic performance of ultrasound elastography (USE) in distinguishing primary Sjögren's syndrome (pSS) from healthy/disease controls.
methodsWe searched the PubMed, Embase, Web of Science, and Cochrane Library databases for published literature on USE for diagnosing pSS. Bivariate random effects models were used to calculate the pooled sensitivity and specificity of USE. To determine the factors influencing heterogeneity, meta-regression and subgroup analyses were performed to assess country, diagnostic criteria, imaging mechanisms, shear wave elastography techniques, measurement location, control group category, and patient age. Publication bias was assessed using the asymmetry of the Deeks funnel plot.
resultsFifteen articles covering 816 patients and 735 control participants were included. USE showed a pooled sensitivity of 0.80 (95% CI: 0.71-0.87) and specificity of 0.87 (95% CI: 0.78-0.92). Meta-regression and subgroup analyses revealed that shear wave elastography techniques, measurement location, and patient age were significant factors that affected study heterogeneity (p < 0.05). Elastography performs better in diagnosing patients aged ≤ 51 years compared to patients aged > 51 years. There was no significant publication bias.
conclusionUSE demonstrates high accuracy in differentiating between pSS and healthy/disease control groups. CLINICAL RELEVANCE STATEMENT: Ultrasound elastography, as a non-invasive and cost-effective technique, can be used to distinguish primary Sjögren's syndrome from disease/healthy control groups by measuring the stiffness of salivary glands. KEY POINTS: • Ultrasound elastography is an acceptable technique for the diagnosis of primary Sjögren's syndrome. • The pooled sensitivity and specificity of ultrasound elastography for diagnosing primary Sjögren's syndrome were 0.80 and 0.87, respectively. • In patients aged ≤ 51 years with primary Sjögren's syndrome, ultrasound elastography showed good diagnostic performance.
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