ArticlePediatric nephrology (Berlin, Germany)2024
Kidney disease progression in pediatric and adult posterior urethral valves (PUV) patients.
Article in Pediatric nephrology (Berlin, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Post-transplant kidney function decline in children with posterior urethral valves versus non-urologic etiologies: roles of catheterization, infection, and rejection.Pediatric nephrology (Berlin, Germany) · 2026Article
- Proteinuria in adolescence.Pediatric nephrology (Berlin, Germany) · 2026Review
- Renal perfusion in dynamic scans: a key predictor of long-term outcomes in posterior urethral valves.Pediatric nephrology (Berlin, Germany) · 2025Observational
- Care of children with posterior urethral valves after initial endoscopic incision/ablation: what a nephrologist needs to know.Pediatric nephrology (Berlin, Germany) · 2025Review
- Long-Term Kidney Outcomes in Children with Posterior Urethral Valves: A Population-Based Cohort Study.Journal of the American Society of Nephrology : JASN · 2024Article
- Review
- Risk Factors for Early Chronic Kidney Disease IV-V in Children with Posterior Urethral Valves: A Retrospective Cohort Study.Journal of Indian Association of Pediatric SurgeonsArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPosterior urethral valves (PUV) is the most common cause of obstructive uropathy in boys; approximately 15% develop kidney failure by early adulthood. However, rates of kidney function decline are poorly defined in PUV children and adults, as is the impact of potentially modifiable chronic kidney disease (CKD) progression risk factors.
methodsWe conducted a retrospective review of all PUV patients followed at our institution from 1995 to 2018. Inclusion criteria were estimated glomerular filtration rate (eGFR) > 20 ml/min/1.73 m
resultsFifty-two PUV patients met the inclusion criteria. Median (interquartile range) eGFR decline was 2.6 (2.1, 3.1) ml/min/1.73 m
conclusionPUV patients show progressive loss of kidney function well into adulthood. Proteinuria and recurrent UTIs are associated with faster progression, suggesting potential modifiable risk factors. This is the first study to report annualized eGFR decline rates in PUV patients, which could help inform the design of clinical trials of CKD therapies.
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