Evidence map›Paper›PMID 37658860›Full record

ArticleEuropean journal of nutrition2023

Plant-based dietary indices and biomarkers of chronic low-grade inflammation: a cross-sectional analysis of adults in Ireland.

Soraeya Kharaty, Janas M Harrington, Seán R Millar, Ivan J Perry, Catherine M Phillips

Open access · hybridAbstract read
In one paragraph

Article in European journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Plant-based diets and urological health.Nature reviews. Urology · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Soraeya KharatySchool of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin 4, Ireland.ORCID http://orcid.org/0000-0002-8021-3027
Janas M HarringtonSchool of Public Health, University College Cork, Cork, Ireland.ORCID http://orcid.org/0000-0002-6238-7031
Seán R MillarSchool of Public Health, University College Cork, Cork, Ireland.ORCID http://orcid.org/0000-0003-4453-8446
Ivan J PerrySchool of Public Health, University College Cork, Cork, Ireland.ORCID http://orcid.org/0000-0002-4965-9792
Catherine M PhillipsSchool of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin 4, Ireland. catherine.phillips@ucd.ie.ORCID http://orcid.org/0000-0003-4916-4463
University College Cork · IEUniversity College Dublin · IE

Funding

Health Research Board HRC/2007/13
6 · The paper itself

Abstract

purposeThere is increasing interest in the health benefits of plant-based diets (PBDs). Evidence reports favourable associations with inflammatory profiles and reduced cardiovascular disease risk. However, limited studies have examined relationships between PBD indices (PDIs) and inflammatory biomarkers. We explored overall PDI, healthful PDI (hPDI) and unhealthful PDI (uPDI) associations with inflammatory biomarker profiles.

methodsThis cross-sectional analysis included 1986 middle- to older-aged adults from the Mitchelstown Cohort. PDI scores were calculated using validated food frequency questionnaires. PDI score associations with inflammatory biomarkers were assessed via linear regression analysis, with adjustment for potential confounders.

resultsComparison of quintiles (Q5 vs Q1) revealed lower concentrations of C-reactive protein (CRP), interleukin 6 (IL-6), white blood cells (WBCs), neutrophils and monocytes, and the leptin-to-adiponectin ratio (PDI and hPDI P < 0.05); lower leptin (PDI, P < 0.05), and complement component 3 (C3), tumour necrosis factor alpha (TNF-α), plasminogen activator inhibitor 1, lymphocytes and eosinophils (hPDI, P < 0.05); and higher concentrations of adiponectin (PDI and hPDI, P < 0.05). Conversely, higher concentrations of C3, CRP, IL-6, TNF-α, resistin, WBCs, neutrophils, lymphocytes, monocytes and eosinophils, and the neutrophil-to-lymphocyte ratio, and lower adiponectin concentrations were observed comparing uPDI quintiles (P < 0.05). In fully adjusted regression models, higher hPDI scores were associated with lower concentrations of C3, TNF-α, WBCs, neutrophils and monocytes (all P < 0.01). Higher uPDI scores were associated with higher C3 and TNF-α concentrations (all P < 0.01).

conclusionThis study provides evidence that a more healthful PBD is associated with a more favourable inflammatory profile and that a more unhealthful PBD is associated with the reverse.

Indexed as

Diet, VegetarianLeptinAdiponectinAdultBiomarkersC-Reactive ProteinCross-Sectional StudiesDietHumansInflammationInterleukin-6IrelandMiddle AgedTumor Necrosis Factor-alphaAdiponectinBiomarkersC-Reactive ProteinInterleukin-6LeptinTumor Necrosis Factor-alphaCardiovascular diseaseCross-sectional studyInflammatory biomarkersMiddle-aged adultsPlant-based dietPlant-based dietary index

Identifiers

PMID37658860
PMCPMC10611858
OpenAlexW4386388169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.