ArticleSleep2024
Altered sleep architecture in diabetes and prediabetes: findings from the Baependi Heart Study.
Article in Sleep, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Sleep quality assessment in hospitalized postoperative surgical patients: a COSMIN-based systematic review.Frontiers in sleep · 2025Pooled it
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- Article
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- Differences in brain spindle density during sleep between patients with and without type 2 diabetes.Computers in biology and medicine · 2025Article
- Sleep-disordered breathing increases mortality in patients with diabetes.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Observational
- The Complex Interaction Between Sleep-Related Information, Misinformation, and Sleep Health: Call for Comprehensive Research on Sleep Infodemiology and Infoveillance.JMIR infodemiology · 2024Article
- Sleep Architecture Changes in Diabetes.Journal of clinical medicine · 2024Review
- Article
- Differences in sleep spindle wave density between patients with diabetes mellitus and matched controls: implications for sensing and regulation of peripheral blood glucose.medRxiv : the preprint server for health sciences · 2024Article
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9 authors at 5 institutions in 3 countries.
Funding
Abstract
STUDY
objectivesPeople with diabetes and prediabetes are more likely to have sleep-disordered breathing (SDB), but few studies examined sleep architecture in people with diabetes or prediabetes in the absence of moderate-severe SDB, which was the aim of our cross-sectional study.
methodsThis cross-sectional sample is from the Baependi Heart Study, a family-based cohort of adults in Brazil. About 1074 participants underwent at-home polysomnography (PSG). Diabetes was defined as fasting glucose >125 mg/dL or HbA1c > 6.4 mmol/mol or taking diabetic medication, and prediabetes was defined as HbA1c ≥ 5.7 & <6.5 mmol/mol or fasting glucose ≥ 100 & ≤125 mg/dl. We excluded participants with an apnea-hypopnea index (AHI) ≥ 30 in primary analyses and ≥ 15 in secondary analysis. We compared sleep stages among the 3 diabetes groups (prediabetes, diabetes, neither).
resultsCompared to those without diabetes, we found shorter REM duration for participants with diabetes (-6.7 min, 95%CI -13.2, -0.1) and prediabetes (-5.9 min, 95%CI -10.5, -1.3), even after adjusting for age, gender, BMI, and AHI. Diabetes was also associated with lower total sleep time (-13.7 min, 95%CI -26.8, -0.6), longer slow-wave sleep (N3) duration (+7.6 min, 95%CI 0.6, 14.6) and higher N3 percentage (+2.4%, 95%CI 0.6, 4.2), compared to those without diabetes. Results were similar when restricting to AHI < 15.
conclusionsPeople with diabetes and prediabetes had less REM sleep than people without either condition. People with diabetes also had more N3 sleep. These results suggest that diabetes and prediabetes are associated with differences in sleep architecture, even in the absence of moderate-severe sleep apnea.
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