Evidence map›Paper›PMID 37658595›Full record

ArticleJournal of medical primatology2023

Viral evolution of SIV chimpanzee toward HIV-1 using humanized mice.

James Z Curlin, Kimberly Schmitt, Leila Remling-Mulder, Corina Valencia Tibbitts, Shelby O'Connor, Preston Marx, Ramesh Akkina

Open access · hybridAbstract read
In one paragraph

Article in Journal of medical primatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

James Z CurlinDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Kimberly SchmittDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Leila Remling-MulderDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Corina Valencia TibbittsDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Shelby O'ConnorDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Preston MarxDepartment of Tropical Medicine, School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
Ramesh AkkinaDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Colorado State University · USUniversity of Wisconsin–Madison · USResearch Institute for Tropical Medicine · PH

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Modeling the molecular evolution of SIV to HIV using humanized miceR01AI123234 · NIAID · COLORADO STATE UNIVERSITY · PI AKKINA, RAMESH · 2016 to 2020
$2.4M
Training Program for Antiretroviral Discovery, Evaluation and Application Research (ADEAR)T32AI150547 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Joshua Adam Barocas, Kristine Mace Erlandson · 2020 to 2026
$1.3M
A dual-purpose hu-mouse model for evaluating SIV and HIV cure strategiesR56AI170230 · NIAID · COLORADO STATE UNIVERSITY · PI AKKINA, RAMESH · 2022 to 2022
$644k
NCATS NIH HHS UL1 TR002535NIAID NIH HHS R01 AI123234NIAID NIH HHS R56 AI170230NIAID NIH HHS T32 AI150547NIH HHS P51 OD011104NIH HHS P51 OD011106
6 · The paper itself

Abstract

HIV-1 emerged from SIVcpz evolving in humans. Humanized mice are an effective tool for assessing viral evolution via measuring viral loads, CD4

Indexed as

HIV-1Pan troglodytesAnimalsHumansMiceSerial PassageViral LoadHIV-1hu-HSC miceserial passagingSIVcpzMB897viral evolution

Identifiers

PMID37658595
PMCPMC10635509
OpenAlexW4386386702

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.