Evidence map›Paper›PMID 37658466›Full record

ArticleJournal of medical case reports2023

Personalized medicine: paradigm shift in ALK positive non-small cell lung cancer: a case report.

João Vasco Barreira, José Leão Mendes, Anuraj Parmanande

Abstract readCase Reports
In one paragraph

Article in Journal of medical case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

João Vasco BarreiraCUF Oncologia, Lisboa, Portugal. joaovascobarreira@gmail.com.ORCID http://orcid.org/0000-0002-4527-5660
José Leão MendesCentro Hospitalar Universitário Lisboa Central, Lisboa, Portugal.ORCID http://orcid.org/0000-0003-2458-1746
Anuraj ParmanandeHospital SAMS, Lisboa, Portugal.ORCID http://orcid.org/0000-0002-1549-5478

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSince the identification of multiple therapeutic targets, as is the case of anaplastic lymphoma kinase (ALK) translocation, the paradigm of treating patients with non-small cell lung cancer (NSCLC) has improved. In order to guarantee the possibility of longer survival outcomes with a better quality of life we must invest in the determination, in suitable time, of the consensual biomarkers and in the availability of the best treatments to our patients. CASE PRESENTATION: We present a case of a caucasian male in his fifth decade of life, non-smoker, who highlights the complex journey of ALK-positive patients. This particular case, demonstrates the efficacy and tolerability of the new ALK target therapies, allowing our patients to maintain their routines without compromising the effectiveness of the therapy.

conclusionFocusing on the reality of ALK positive patients and the impact that this therapy has on the daily lives of our patients, we can contribute to the awareness of this specific pathology.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsHumansMalePrecision MedicineQuality of LifeTranslocation, GeneticALK-rearranged NSCLCNon-small cell lung cancer (NSCLC)OncologyTarget Therapy

Identifiers

PMID37658466
PMCPMC10474633

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.