SynthesisWorld journal of emergency surgery : WJES2023
Diagnostic accuracy of biomarkers to detect acute mesenteric ischaemia in adult patients: a systematic review and meta-analysis.
Synthesis in World journal of emergency surgery : WJES, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- CIRSE Standards of Practice for the Interventional Radiology Management of Acute and Chronic Arterial Mesenteric Ischaemia.Cardiovascular and interventional radiology · 2025Guideline
- Radiological diagnosis of acute mesenteric ischemia in adult patients: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Diagnostic and Prognostic Factors in Acute Intestinal Ischemia: A Comparative, Retrospective, Single-Center Cohort Study.Journal of clinical medicine · 2026Article
- Predictive Value of Imaging-Based Classifications for Conservative Management Failure in Isolated Superior Mesenteric Artery Dissection.JACC. Asia · 2026Article
- Beyond Classification: Rethinking Risk Stratification in Isolated Superior Mesenteric Artery Dissection.JACC. Asia · 2026Article
- The Diagnostic Value of D-Dimer Testing in the Differential Diagnosis of Acute Abdomen in the Emergency Department.Journal of clinical medicine · 2026Review
- Current Evidence on the Use of Biomarkers for the Diagnosis of Acute Mesenteric Ischemia: A Narrative Review.Cureus · 2026Review
- Development and validation of machine learning-based prediction models for adult bowel necrosis for patients presenting with acute abdominal pain at the emergency department: a multicenter retrospective cohort study.BMC medical informatics and decision making · 2026Article
- Diagnostic value of hypoxia-inducible factor 1 alpha and adrenomedullin in acute mesenteric ischemia.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- A Risk Model Incorporating the Novel Inflammatory Biomarker CD64 for Predicting Bloodstream Infection in Suspected Cases.Antibiotics (Basel, Switzerland) · 2026Article
- The challenging diagnosis of ICU-related Mesenteric Ischaemia: a prospective, observational, multicentre cohort.Annals of intensive care · 2026Article
- Predictive factors for mortality in acute mesenteric ischemia.Frontiers in surgery · 2026Article
- Plasma levels of intestinal fatty acid-binding protein and citrulline are not associated with severe upper gastrointestinal ischemic lesions after out-of-hospital cardiac arrest: an ancillary study of the ENTRACT trial.Resuscitation plus · 2026Article
- Small Bowel Ischemia Secondary to Splanchnic Venous Thrombosis in a Postpartum Patient-A Case Report.International medical case reports journal · 2026Article
- The Role of High-Sensitivity Cardiac Troponin and Ischemia-Modified Albumin in Patients with Lower Extremity Peripheral Arterial Disease.International journal of molecular sciences · 2025Review
- Refining patient stratification and treatment decision-making in acute SMA occlusion.World journal of emergency surgery : WJES · 2025Article
- Diagnostic utility of inflammatory ratios and nutritional scores in acute mesenteric ischemia: A retrospective single-center study.Turkish journal of surgery · 2025Article
- A predictive clinical-radiomics nomogram for early diagnosis of mesenteric arterial embolism based on non-contrast CT and biomarkers.Abdominal radiology (New York) · 2025Article
- Homocysteine(HCY), a novel biomarker for predicting irreversible transmural intestinal necrosis in patients with adhesive small bowel obstruction: results from a prospective observational study.World journal of emergency surgery : WJES · 2025Observational
- A Deep Learning Model for Identifying the Risk of Mesenteric Malperfusion in Acute Aortic Dissection Using Initial Diagnostic Data: Algorithm Development and Validation.Journal of medical Internet research · 2025Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute mesenteric ischaemia (AMI) is a disease with different pathophysiological mechanisms, leading to a life-threatening condition that is difficult to diagnose based solely on clinical signs. Despite widely acknowledged need for biomarkers in diagnosis of AMI, a broad systematic review on all studied biomarkers in different types of AMI is currently lacking. The aim of this study was to estimate the diagnostic accuracy of all potential biomarkers of AMI studied in humans.
methodsA systematic literature search in PubMed, The Cochrane Library, Web of Science and Scopus was conducted in December 2022. Studies assessing potential biomarkers of AMI in (at least 10) adult patients and reporting their diagnostic accuracy were included. Meta-analyses of biomarkers' sensitivity, specificity, and positive and negative likelihood ratios were conducted. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed, and the study quality was assessed with the QUADAS-2 tool.
resultsSeventy-five studies including a total of 9914 patients assessed 18 different biomarkers in serum/plasma and one in urine (each reported in at least two studies), which were included in meta-analyses. None of the biomarkers reached a conclusive level for accurate prediction. The best predictive value overall (all studies with any type and stage of AMI pooled) was observed for Ischaemia-modified albumin (2 studies, sensitivity 94.7 and specificity 90.5), interleukin-6 (n = 4, 96.3 and 82.6), procalcitonin (n = 6, 80.1 and 86.7), and intestinal fatty acid-binding protein (I-FABP) measured in serum (n = 16, 73.9 and 90.5) or in urine (n = 4, 87.9 and 78.9). In assessment of transmural mesenteric ischaemia, urinary I-FABP (n = 2, 92.3 and 85.2) and D-dimer (n = 3, 87.6 and 83.6) showed moderate predictive value. Overall risk of bias was high, mainly because of selected study populations and unclear timings of the biomarker measurements after onset of symptoms. Combinations of biomarkers were rarely studied, not allowing meta-analyses.
conclusionsNone of the studied biomarkers had sufficient sensitivity and specificity to diagnose AMI, although some biomarkers showed moderate predictive accuracy. Future studies should focus on timing of measurements of biomarkers, distinguishing between early stage and transmural necrosis, and between different types of AMI. Additionally, studies on combinations of biomarkers are warranted. PROSPERO registration: CRD42022379341.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.