Evidence map›Paper›PMID 37658124›Full record

ArticlePediatric research2024

Outcomes up to age 36 months after congenital Zika virus infection-U.S. states.

Varsha Neelam, Kate R Woodworth, Daniel J Chang, Nicole M Roth, Megan R Reynolds, Amanda Akosa, Christopher P Carr, Kayla N Anderson, Sarah B Mulkey, Roberta L DeBiasi and 52 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

62 authors at 20 institutions in 1 country.

Varsha NeelamDivision of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA. pju4@cdc.gov.ORCID 0000-0001-9900-3567
Kate R WoodworthDivision of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Daniel J ChangOak Ridge Institute for Science and Education, Oak Ridge, TN, USA.
Nicole M RothDivision of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Megan R ReynoldsDivision of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Amanda AkosaDivision of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Christopher P CarrOak Ridge Institute for Science and Education, Oak Ridge, TN, USA.
Kayla N AndersonDivision of Violence Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Sarah B MulkeyChildren's National Hospital, Washington, D. C., USA.
Roberta L DeBiasiChildren's National Hospital, Washington, D. C., USA.
Cara BiddleChildren's National Hospital, Washington, D. C., USA.
Ellen H LeeNew York City Department of Health & Mental Hygiene, New York City, NY, USA.
Amanda L ElmoreFlorida Department of Health, Tampa, FL, USA.
Sarah J ScotlandMassachusetts Department of Public Health, Boston, MA, USA.
Similoluwa SowunmiCalifornia Department of Public Health, Sacramento, CA, USA.
Nicole D LongcoreNew York State Department of Health, Albany, NY, USA.
Muhammad AhmedNew Jersey Department of Health, Trenton, NJ, USA.
Peter H LangloisTexas Department of State Health Services, Austin, TX, USA.
Salma KhuwajaHouston Health Department, Houston, TX, USA.
Shea Elizabeth BrowneVirginia Department of Health, Richmond, VA, USA.
Leah LindPennsylvania Department of Health, Pittsburgh, PA, USA.
Kyoo ShimDallas County Health and Human Services, Dallas, TX, USA.
Michael GosciminskiRhode Island Department of Health, Providence, RI, USA.
Rachel BlumenfeldPhiladelphia Department of Public Health, Philadelphia, PA, USA.
Shreya KhuntiaDistrict of Columbia Department of Health, Washington, D. C, USA.
Umme-Aiman HalaiLos Angeles County Department of Public Health, Los Angeles, CA, USA.
Autumn LocklearNorth Carolina Department of Health and Human Services, Chapel Hill, NC, USA.
Mary ChanWashington State Department of Health, Seattle, WA, USA.
Teri' WillabusGeorgia Department of Public Health, Atlanta, GA, USA.
Julius TonzelLouisiana Department of Health, New Orleans, LA, USA.
Natalie S MarzecColorado Department of Public Health and Environment, Denver, CO, USA.
Nianest Alers BarretoHawaii Department of Health, Honolulu, HI, USA.
Connie SanchezHidalgo County Health & Human Services Department, Hidalgo, TX, USA.
Jane FornoffIllinois Department of Public Health, Springfield, IL, USA.
Shelby HaleOhio Department of Health, Columbus, OH, USA.
Amy NanceUtah Department of Health and Human Services, Salt Lake City, UT, USA.
Lisa IguchiOregon Health Authority, Salem, OR, USA.
Sowmya N AdibhatlaWisconsin Department of Health Services, Madison, WI, USA.
Emily PottsIndiana Department of Health, Indianapolis, IN, USA.
Elizabeth SchiffmanMinnesota Department of Health, Minneapolis, MN, USA.
Devin RamanSouthern Nevada Health District, Las Vegas, NV, USA.
Morgan F McDonaldTennessee Department of Health, Nashville, TN, USA.
Brandi StricklinArkansas Department of Health, Little Rock, AR, USA.
Elizabeth LudwigNebraska Department of Health and Human Services, Lincoln, NE, USA.
Lindsay DensonOklahoma State Department of Health, Oklahoma City, OK, USA.
Dianna ContrerasArizona Department of Health Services, Tempe, AZ, USA.
Paul A RomittiUniversity of Iowa College of Public Health, Iowa City, IA, USA.
Emily FerrellKentucky Department for Public Health, Georgetown, KY, USA.
Meghan MarxSouth Dakota Department of Health, Pierre, SD, USA.
Kimberly SignsMichigan Department of Health and Human Services, Lansing, MI, USA.
Amie CookKansas Department of Health and Environment, Topeka, KS, USA.
Vinita Oberoi LeedomSouth Carolina Department of Health and Environmental Control, Florence, SC, USA.
Suzann BeauregardNew Hampshire Department of Health and Human Services, Concord, NH, USA.
Lucia C OrantesVermont Department of Health, Burlington, VT, USA.
Laura CronquistNorth Dakota Department of Health, Bismarck, ND, USA.
Lesley RoushWest Virginia Bureau for Public Health, Charleston, WV, USA.
Shana Godfred-CatoDivision of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Suzanne M GilboaDivision of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Dana Meaney-DelmanDivision of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Margaret A HoneinDivision of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Cynthia A MooreGoldbelt Professional Services, LLC, Chesapeake, VA, USA.
Van T TongDivision of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Centers for Disease Control and Prevention · USChildren's National · USOak Ridge Associated Universities · USVirginia Department of Health · USArizona Department of Health Services · USArkansas Department of Health · USCalifornia Department of Public Health · USColorado Department of Public Health and Environment · USDallas County · USDistrict of Columbia Department of Health · USFlorida Department of Health · USGeorgia Department of Public Health · USHawaii Department of Health · USHouston Health and Human Services Department · USIllinois Department of Public Health · USIndiana State Department of Health · USKansas Department of Health and Environment · USKentucky Department for Public Health · USLos Angeles County Department of Public Health · USLouisiana State Department of Health and Hospitals · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundTo characterize neurodevelopmental abnormalities in children up to 36 months of age with congenital Zika virus exposure.

methodsFrom the U.S. Zika Pregnancy and Infant Registry, a national surveillance system to monitor pregnancies with laboratory evidence of Zika virus infection, pregnancy outcomes and presence of Zika associated birth defects (ZBD) were reported among infants with available information. Neurologic sequelae and developmental delay were reported among children with ≥1 follow-up exam after 14 days of age or with ≥1 visit with development reported, respectively.

resultsAmong 2248 infants, 10.1% were born preterm, and 10.5% were small-for-gestational age. Overall, 122 (5.4%) had any ZBD; 91.8% of infants had brain abnormalities or microcephaly, 23.0% had eye abnormalities, and 14.8% had both. Of 1881 children ≥1 follow-up exam reported, neurologic sequelae were more common among children with ZBD (44.6%) vs. without ZBD (1.5%). Of children with ≥1 visit with development reported, 46.8% (51/109) of children with ZBD and 7.4% (129/1739) of children without ZBD had confirmed or possible developmental delay.

conclusionUnderstanding the prevalence of developmental delays and healthcare needs of children with congenital Zika virus exposure can inform health systems and planning to ensure services are available for affected families. IMPACT: We characterize pregnancy and infant outcomes and describe neurodevelopmental abnormalities up to 36 months of age by presence of Zika associated birth defects (ZBD). Neurologic sequelae and developmental delays were common among children with ZBD. Children with ZBD had increased frequency of neurologic sequelae and developmental delay compared to children without ZBD. Longitudinal follow-up of infants with Zika virus exposure in utero is important to characterize neurodevelopmental delay not apparent in early infancy, but logistically challenging in surveillance models.

Indexed as

MicrocephalyNeurodevelopmental DisordersPregnancy Complications, InfectiousZika VirusZika Virus InfectionChildChild, PreschoolFemaleHumansInfantInfant, NewbornPregnancy

Identifiers

PMID37658124
PMCPMC10913023
OpenAlexW4386378219

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.