Evidence map›Paper›PMID 37658022›Full record

ArticleTrends in cancer2023

Interferon signaling restrains renal cell carcinoma heterogeneity.

Peter Holicek, Jitka Fucikova, Lorenzo Galluzzi

Open access · greenAbstract readComment
In one paragraph

Article in Trends in cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 67% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

Peter HolicekSotio Biotech a.s., Prague, Czech Republic; Second Medical Faculty, Charles University, Prague, Czech Republic.
Jitka FucikovaSotio Biotech a.s., Prague, Czech Republic; Second Medical Faculty, Charles University, Prague, Czech Republic.
Lorenzo GalluzziDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA. Electronic address: deadoc80@gmail.com.
Charles University · CZCornell University · US

Funding

Radiation Effect on Immune Cells and the MicrobiomeU54CA274291 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Encouse Golden · 2022 to 2026
$9.1M
Targeting the BCL2 immune checkpoint to enhance the immunostimulatory effects of radiation in breast cancerR01CA271915 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Lorenzo Galluzzi · 2023 to 2026
$2.9M
NCI NIH HHS R01 CA271915NCI NIH HHS U54 CA274291
6 · The paper itself

Abstract

Type I interferon (IFN) is central to cancer surveillance as it mediates both direct and immune-mediated oncosuppressive effects. A recent study by Perelli et al. suggests that the ability of renal cancer cells to tolerate complex karyotypic alterations elicited by chromosomal instability (CIN), and ultimately acquire full metastatic potential, is also negatively regulated by IFN signaling.

Indexed as

Carcinoma, Renal CellInterferon Type IKidney NeoplasmsHumansNucleotidyltransferasesSignal TransductionInterferon Type INucleotidyltransferasescancer/immunity coevolutioncancer stem cellsCGASCNVimmunoevasion

Identifiers

PMID37658022
PMCPMC11075004
OpenAlexW4386295283

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.