Evidence map›Paper›PMID 37657958›Full record

ArticleAnais brasileiros de dermatologia

Decrease of 5-hydroxymethylcytosine in primary cutaneous CD4

Jiahui Hu, Xinyue Zhang, Lihong Zhao, Qiang Zhao, Songmei Geng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anais brasileiros de dermatologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jiahui HuDepartment of Dermatology, The Second Affiliated Hospital, School of Medicine, Xian Jiaotong University, Xian, China.
Xinyue ZhangDepartment of Dermatology, The Second Affiliated Hospital, School of Medicine, Xian Jiaotong University, Xian, China.
Lihong ZhaoDepartment of Dermatology, The Second Affiliated Hospital, School of Medicine, Xian Jiaotong University, Xian, China.
Qiang ZhaoDepartment of Dermatology, The Second Affiliated Hospital, School of Medicine, Xian Jiaotong University, Xian, China.
Songmei GengDepartment of Dermatology, The Second Affiliated Hospital, School of Medicine, Xian Jiaotong University, Xian, China. Electronic address: gsm312@yahoo.com.
Second Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary cutaneous CD4

objectivesThe authors aimed to explore the role of differential 5-hmC immunostaining as a useful marker to distinguish PC-SMTLD from PL.

methodsRetrospective case series study with immunohistochemical and immunofluorescence analysis of 5-hmC was performed in PL and PC-SMTLD.

resultsSignificant decrease of 5-hmC nuclear staining was observed in PC-SMTLD when compared with PL (p < 0.0001). By semi-quantitative grade integration, there were statistical differences in the final 5-hmC scores in the two study groups. The IF co-staining of 5-hmC with CD4 revealed a decrease of 5-hmC in CD4 STUDY LIMITATIONS: The small clinical sample size of the study.

conclusionsThe immunorreactivity of 5-hmC in CD4

Indexed as

Lymphoma, T-Cell, CutaneousPseudolymphomaSkin Neoplasms5-MethylcytosineCD4-Positive T-LymphocytesHumansRetrospective Studies5-hydroxymethylcytosine5-MethylcytosineCutaneous T-cell lymphomaDNA methylationEpigenomics

Identifiers

PMID37657958
PMCPMC10964357
OpenAlexW4386286736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.