Evidence map›Paper›PMID 37657560›Full record

ArticleJournal of thrombosis and haemostasis : JTH2023

A regulatory node involving Gα

Shuchi Gupta, Matthew Cooper, Xuefei Zhao, Yanki Yarman, Hannah Thomson, Daniel DeHelian, Lawrence F Brass, Peisong Ma

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Shuchi GuptaDepartment of Medicine and the Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Matthew CooperDepartment of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Xuefei ZhaoDepartment of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Yanki YarmanDepartment of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Hannah ThomsonDepartment of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Daniel DeHelianDepartment of Medicine and the Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Lawrence F BrassDepartment of Medicine and the Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Peisong MaDepartment of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address: peisong.ma@jefferson.edu.
Thomas Jefferson University · USTranslational Therapeutics (United States) · US

Funding

Mechanism for feedback regulation of G protein-coupled receptor signaling in plateletsR01HL144574 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI MA, PEISONG · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL144574
6 · The paper itself

Abstract

backgroundMost platelet agonists work through G protein-coupled receptors, activating pathways that involve members of the G

objectivesTo identify and characterize mechanisms by which G

methodsBased on our prior experience with a Gα RESULTS AND

conclusionsAs predicted, the G188S substitution in Gα

Indexed as

Blood PlateletsGTP-Binding Protein alpha Subunits, Gq-G11RGS ProteinsAnimalsMicePhospholipase C betaPlatelet ActivationReceptors, G-Protein-CoupledSignal TransductionGTP-Binding Protein alpha Subunits, Gq-G11Phospholipase C betaPlcb3 protein, mouseReceptors, G-Protein-CoupledRGS ProteinsG protein-coupled receptorshemostasisplateletssignaling networks

Identifiers

PMID37657560
PMCPMC10840692
OpenAlexW4386295772

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.