ReviewCell2023
Biomarkers of aging for the identification and evaluation of longevity interventions.
2 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph
Review in Cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 421 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
421citing papers in PubMed, 1 pooled it
85.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Searching for Longevity Genes in the Historically Unique Ashkenazi Jewish Population
Taining Golden Lake Comprehensive Chronic Disease Management Initiative
Who cites it
421 citing papers in PubMed, 1 synthesis or guideline pooled it, 552 citations in OpenAlex.
- Accelerated epigenetic age in hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Pooled it
- Epigenetic aging biomarkers in dietary geroscience: feasibility, participant perceptions, and trial design considerations.GeroScience · 2026Trial
- Study protocol for FAXAge: a randomized, controlled clinical trial of fasting and exercise to slow aging in humans.GeroScience · 2026Trial
- Effects of daily multivitamin-multimineral supplementation on metabolomic profiles: 2-year findings from the COSMOS randomized clinical trial.GeroScience · 2026Trial
- Urate-Related Genetic Risk Modulates the Anti-Aging Effects of Exogenous Nucleotides: Multi-Omics Evidence From Older Adults.Aging cell · 2026Trial
- Trial
- Effects of daily multivitamin-multimineral and cocoa extract supplementation on epigenetic aging clocks in the COSMOS randomized clinical trial.Nature medicine · 2026Trial
- DELTA: Strengthening human biological resilience with an N=1 digital health and dynamic biomarker protocol.PloS one · 2026Trial
- Epigenetic Age Acceleration and Cardiometabolic Biomarkers in Response to Weight-Loss Dietary Interventions Among Obese Individuals: The MACRO Trial.Aging cell · 2025Trial
- Nucleotides as an Anti-Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study).Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Trial
- Associations of Green Space and Air Pollution Mixture with Heterogeneous Biological Aging Patterns.Environmental health perspectives · 2026Article
- Glycemic status-dependent proteomic signatures of biological aging for health risk prediction.GeroScience · 2026Article
- Article
- A Deep-Learning Based Biomarker of Systemic Cellular Senescence Burden to Predict Mortality and Health Outcomes.Aging cell · 2026Article
- Exploring Epigenetic Aging and Cognitive Change in Middle Adulthood.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Transplanted hearts assimilate the recipient's biological age.bioRxiv : the preprint server for biology · 2026Article
- Deep learning-derived retinal age gap and its associations with lifestyle, systemic, and ocular health in a health screening cohort.GeroScience · 2026Article
- Aging as Loss of Biological Self-Correction: A Geroscience Framework for Longevity, Inflammaging, and Restored Resilience.Geriatrics (Basel, Switzerland) · 2026Review
- FinnDiane LifeOne Study: influence of ageing on people with type 1 diabetes - a prospective observational cohort study protocol.BMJ open · 2026Article
- The Hallmarks of Aging: From Molecular Mechanisms to Clinical Translation.International journal of molecular sciences · 2026Review
361 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 20 institutions in 12 countries.
Mahdi MoqriDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Genetics, School of Medicine, Stanford University, Stanford, CA, USA; Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA, USA.
Chiara HerzogEuropean Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria.
Jesse R PoganikDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Biomarkers of Aging Consortium
Jamie JusticeDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Daniel W BelskyDepartment of Epidemiology, Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA.
Albert Higgins-ChenDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Alexey MoskalevInstitute of Biogerontology, Lobachevsky University, Nizhny Novgorod, Russia.
Georg FuellenInstitute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center, Rostock, Germany; School of Medicine, University College Dublin, Dublin, Ireland.
Alan A CohenDepartment of Environmental Health Sciences, Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA.
Ivan BautmansGerontology Department, Vrije Universiteit Brussel, Brussels, Belgium; Frailty in Ageing Research Department, Vrije Universiteit Brussel, Brussels, Belgium.
Martin WidschwendterEuropean Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria; Department of Women's Cancer, EGA Institute for Women's Health, University College London, London, UK; Department of Women's and Children's Health, Division of Obstetrics and Gynaecology, Karolinska Institutet, Stockholm, Sweden.
Jingzhong DingGerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Alexander FlemingKitalys Institute, Charlottesville, VA, USA.
Joan MannickTornado Therapeutics, New York, NY, USA.
Jing-Dong Jackie HanPeking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology, Peking University, Beijing, China.
Alex ZhavoronkovInsilico Medicine Hong Kong, Pak Shek Kok, New Territories, Hong Kong SAR, China.
Nir BarzilaiInstitute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.
Matt KaeberleinDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Steven CummingsSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Brian K KennedyHealthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Luigi FerrucciNational Institute on Aging, Baltimore, MD, USA.
Steve HorvathAltos Labs, San Diego, CA, USA.
Eric VerdinBuck Institute for Research on Aging, Novato, CA, USA.
Andrea B MaierDepartment of Human Movement Sciences, @AgeAmsterdam, Amsterdam Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Centre for Healthy Longevity, @AgeSingapore, National University Health System, Singapore, Singapore.
Michael P SnyderDepartment of Genetics, School of Medicine, Stanford University, Stanford, CA, USA. Electronic address: mpsnyder@stanford.edu.
Vittorio SebastianoDepartment of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA, USA. Electronic address: vsebast@stanford.edu.
Vadim N GladyshevDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: vgladyshev@rics.bwh.harvard.edu.
Columbia University · USHarvard University · USUniversität Innsbruck · ATWake Forest University · USAlbert Einstein College of Medicine · USAltos LabsBrigham and Women's Hospital · USBuck Institute for Research on Aging · USCalifornia Pacific Medical Center · USCenter for Life Sciences · CNNational Institute on Aging · USNational University Health System · SGNational University of Singapore · SGN. I. Lobachevsky State University of Nizhny Novgorod · RUStanford Medicine · USStanford University · USUniversity of Rostock · DEUniversity of Washington · USVrije Universiteit Brussel · BEYale University · US
Funding
The effects of immune-age on immune-response and the molecular mechanisms which drive itP01AI153559 · NIAID · STANFORD UNIVERSITY · PI DAVIS, MARK MORRIS · 2021 to 2025
$17.8MQUANTITATIVE ASSESSMENT OF BIOLOGICAL AGE AND ITS APPLICATIONSR01AG065403 · NIA · YALE UNIVERSITY · PI Vadim N. Gladyshev, Albert Tzongyang Higgins-Chen · 2020 to 2026
$4.2MUnbiased identification of interventions that extend lifespanR01AG067782 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI GLADYSHEV, VADIM N. · 2019 to 2023
$3.5MRole of rare damaging mutations in agingR01AG064223 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI GLADYSHEV, VADIM N. · 2020 to 2024
$2.8MNIAID NIH HHS P01 AI153559NIA NIH HHS R01 AG064223NIA NIH HHS R01 AG065403NIA NIH HHS R01 AG067782
Abstract
With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.
Indexed as
AgingLongevityBiomarkersHumansBiomarkers
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT00707694ClinicalTrials.gov
NCT07308314ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.