Evidence map›Paper›PMID 37656908›Full record

ArticleJournal of biochemistry2023

Curcumin analog GO-Y030 inhibits tumor metastasis and glycolysis.

Takashi MaruYama, Hirofumi Miyazaki, Taishi Komori, Shion Osana, Hiroyuki Shibata, Yuji Owada, Shuhei Kobayashi

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Takashi MaruYamaDepartment of Organ Anatomy, Tohoku University Graduate School of Medicine, Seiryo 2-1, Aoba, Sendai, Miyagi, 980-8575, Japan.ORCID 0000-0003-0820-3219
Hirofumi MiyazakiDepartment of Organ Anatomy, Tohoku University Graduate School of Medicine, Seiryo 2-1, Aoba, Sendai, Miyagi, 980-8575, Japan.
Taishi KomoriMolecular Biology of Bones and Teeth Section, National Institute of Dental and Craniofacial Research(NIDCR), National Institutes of Health, 30 convent drive, Building 30, Bethesda, MD, 20892, USA.
Shion OsanaDepartment of Engineering Science, University of Electro-Communications, Graduate School of Informatics and Engineering, Chofugaoka 1-5-1, Chofu, Tokyo, 182-8585, Japan.
Hiroyuki ShibataDepartment of Clinical Oncology, Akita University, Graduate School of Medicine, Hondo 1-1, Akita, Akita, 010-8543, Japan.
Yuji OwadaDepartment of Organ Anatomy, Tohoku University Graduate School of Medicine, Seiryo 2-1, Aoba, Sendai, Miyagi, 980-8575, Japan.
Shuhei KobayashiDepartment of Organ Anatomy, Tohoku University Graduate School of Medicine, Seiryo 2-1, Aoba, Sendai, Miyagi, 980-8575, Japan.
Tohoku University · JPAkita University · JPNational Institutes of Health · USUniversity of Electro-Communications · JP

Funding

Grant-in-Aid for Scientific Research (C) 20K11546Intramural Research Program of NIDCR and a Grant-in-Aid for Scientific Research (B) 22H03526Mishima Kaiun Memorial Foundation A-157
6 · The paper itself

Abstract

Tumor metastasis is one of the worst prognostic features of cancer. Although metastasis is a major cause of cancer-related deaths, an effective treatment has not yet been established. Here, we explore the antitumor effects of GO-Y030, a curcumin analog, via various mechanisms using a mouse model. GO-Y030 treatment of B16-F10 melanoma cells inhibited TGF-β expression and glycolysis. The invasion assay results showed almost complete invasion inhibition following GO-Y030 treatment. Mouse experiments demonstrated that GO-Y030 administration inhibited lung tumor metastasis without affecting vascular endothelial cells. Consistent with this result, GO-Y030 treatment led to the downregulation of MMP2 and VEGFα, inhibiting tumor invasion and metastasis. The silencing of eIF4B, a downstream molecule of S6, attenuated MMP2 expression. Our study demonstrates the novel efficacy of GO-Y030 in inhibiting tumor metastasis by regulating metastasis-associated gene expression via inhibiting dual access, glycolytic and TGF-β pathways.

Indexed as

CurcuminNeoplasmsBenzene DerivativesCell Line, TumorEndothelial CellsHumansKetonesMatrix Metalloproteinase 2Neoplasm MetastasisTransforming Growth Factor beta1,5-bis(3,5-bis(methoxymethoxy)phenyl)penta-1,4-dien-3-oneBenzene DerivativesCurcuminKetonesMatrix Metalloproteinase 2Transforming Growth Factor betacurcumin analogmatrix metallopeptidase 2migration assayscratching assaytumor metastasis

Identifiers

PMID37656908
PMCPMC11002536
OpenAlexW4386356831

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.