ArticlePLoS genetics2023
Purging due to self-fertilization does not prevent accumulation of expansion load.
Article in PLoS genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The consequences of partial clonality on the spatiotemporal genetic structure of the red alga Chondria tumulosa (Ceramiales, Rhodophyta).Journal of phycology · 2026Article
- Evolutionary Consequences of Repeated Loss of Distyly in Linum.Genome biology and evolution · 2026Article
- What has population genomics told us about the dynamics of selection and plant adaptation?Molecular biology and evolution · 2026Review
- Joint test of historical vs. contemporary biogeography supports abundant center hypothesis shaping spatial patterns of self-fertilization.Evolution letters · 2026Article
- Population Genomics of Incipient Allochronic Divergence in the Pine Processionary Moth.Molecular ecology · 2025Article
- A Test of the Long-Term Efficiency of Genetic Rescue With Drosophila melanogaster.Molecular ecology · 2025Article
- An alpine plant shows no decrease in genetic diversity associated with rapid post-glacial range expansion.American journal of botany · 2025Article
- Whole-genome duplication increases genetic diversity and load in outcrossingProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Can ploidy changes propel the evolution of allogamy in a selfing species complex?BMC plant biology · 2025Article
- Unveiling the Genome-Wide Consequences of Range Expansion and Mating System Transitions in Primula vulgaris.Genome biology and evolution · 2024Article
- Using Runs of Homozygosity and Machine Learning to Disentangle Sources of Inbreeding and Infer Self-Fertilization Rates.Genome biology and evolution · 2024Article
- Integrating very high resolution environmental proxies in genotype-environment association studies.Evolutionary applications · 2024Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As species expand their geographic ranges, colonizing populations face novel ecological conditions, such as new environments and limited mates, and suffer from evolutionary consequences of demographic change through bottlenecks and mutation load accumulation. Self-fertilization is often observed at species range edges and, in addition to countering the lack of mates, is hypothesized as an evolutionary advantage against load accumulation through increased homozygosity and purging. We study how selfing impacts the accumulation of genetic load during range expansion via purging and/or speed of colonization. Using simulations, we disentangle inbreeding effects due to demography versus due to selfing and find that selfers expand faster, but still accumulate load, regardless of mating system. The severity of variants contributing to this load, however, differs across mating system: higher selfing rates purge large-effect recessive variants leaving a burden of smaller-effect alleles. We compare these predictions to the mixed-mating plant Arabis alpina, using whole-genome sequences from refugial outcrossing populations versus expanded selfing populations. Empirical results indicate accumulation of expansion load along with evidence of purging in selfing populations, concordant with our simulations, suggesting that while purging is a benefit of selfing evolving during range expansions, it is not sufficient to prevent load accumulation due to range expansion.
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