Evidence map›Paper›PMID 37656622›Full record

ArticleCell reports2023

Metabolic transcriptomics dictate responses of cone photoreceptors to retinitis pigmentosa.

Sang Joon Lee, Douglas Emery, Eric Vukmanic, Yekai Wang, Xiaoqin Lu, Wei Wang, Enzo Fortuny, Robert James, Henry J Kaplan, Yongqing Liu and 2 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Selective deletion ofiScience · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Sang Joon LeeDepartment of Medicine, Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40202, USA; Department of Ophthalmology, Kosin University College of Medicine, #262 Gamcheon-ro, Seo-gu, Busan 49267, Korea.
Douglas EmeryDepartment of Medicine, Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40202, USA.
Eric VukmanicDepartment of Medicine, Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40202, USA.
Yekai WangDepartments of Ophthalmology and Visual Sciences and Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV 26506, USA.
Xiaoqin LuDepartment of Medicine, Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40202, USA.
Wei WangDepartment of Ophthalmology and Visual Sciences, University of Louisville Health Sciences Center, Louisville, KY 40202, USA.
Enzo FortunyDepartment of Neurosurgery, University of Louisville Health Sciences Center, Louisville, KY 40202, USA.
Robert JamesDepartment of Neurosurgery, University of Louisville Health Sciences Center, Louisville, KY 40202, USA.
Henry J KaplanDepartment of Ophthalmology, St. Louis University School of Medicine, St. Louis MO 63110, USA.
Yongqing LiuDepartment of Medicine, Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40202, USA.
Jianhai DuDepartments of Ophthalmology and Visual Sciences and Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV 26506, USA. Electronic address: jianhai.du@hsc.wvu.edu.
Douglas C DeanDepartment of Medicine, Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40202, USA. Electronic address: douglas.dean@louisville.edu.
University of Louisville · USWest Virginia University · USSaint Louis University · US

Funding

Blood outer retina barrier regulationR01EY030933 · NEI · UNIVERSITY OF LOUISVILLE · PI DOUGLAS Chase DEAN · 2020 to 2026
$4.3M
Metabolic dysfunction from ECM remodeling in diseases of human RPER01EY034364 · NEI · UNIVERSITY OF WASHINGTON · PI Jennifer Rayming Chao, Jianhai Du · 2022 to 2026
$2.8M
Cone Rescue in Retinitis PigmentosaR01EY026158 · NEI · UNIVERSITY OF LOUISVILLE · PI DEAN, DOUGLAS CHASE, MCCALL, MAUREEN A · 2016 to 2019
$2.4M
Retinal Mitochondrial Metabolism in Alzheimer's DiseaseR01EY031324 · NEI · WEST VIRGINIA UNIVERSITY · PI DU, JIANHAI · 2021 to 2024
$2.0M
Proline metabolism in retinal healthR01EY032462 · NEI · WEST VIRGINIA UNIVERSITY · PI DU, JIANHAI · 2021 to 2025
$1.9M
Metabolism of AMD iPSC-derived RPEU01EY034591 · NEI · UNIVERSITY OF WASHINGTON · PI CHAO, JENNIFER RAYMING, DU, JIANHAI · 2022 to 2024
$1.3M
NEI NIH HHS R01 EY026158NEI NIH HHS R01 EY030933NEI NIH HHS R01 EY031324NEI NIH HHS R01 EY032462NEI NIH HHS R01 EY034364NEI NIH HHS U01 EY034591
6 · The paper itself

Abstract

Most mutations in retinitis pigmentosa (RP) arise in rod photoreceptors, but cone photoreceptors, responsible for high-resolution daylight and color vision, are subsequently affected, causing the most debilitating features of the disease. We used mass spectroscopy to follow

Indexed as

Retinal Cone Photoreceptor CellsRetinitis PigmentosaHumansReactive Oxygen SpeciesRetinaTranscriptomeReactive Oxygen Speciescone metabolismCP: Neuroscienceglucose transportlactate metabolismphotoreceptor metabolic and epigenetic transcriptomesretinitis pigmentosarod metabolismsingle cell RNA sequencing

Identifiers

PMID37656622
PMCPMC10591869
OpenAlexW4386314751

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.