Evidence map›Paper›PMID 37656249›Full record

ReviewVirchows Archiv : an international journal of pathology2023

The many faces of nodal and splenic marginal zone lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.

Alberto Zamò, Michiel van den Brand, Fina Climent, Laurence de Leval, Stefan Dirnhofer, Lorenzo Leoncini, Siok-Bian Ng, Sarah L Ondrejka, Leticia Quintanilla-Martinez, Lorinda Soma and 1 more

Erratum issuedAbstract readReview
In one paragraph

Review in Virchows Archiv : an international journal of pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Alberto ZamòInstitute of Pathology, University of Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany. alberto.zamo@uni-wuerzburg.de.ORCID http://orcid.org/0000-0001-6203-7966
Michiel van den BrandPathology-DNA, Location Rijnstate Hospital, Wagnerlaan 55, 6815AD, Arnhem, The Netherlands. mvandenbrand@rijnstate.nl.ORCID https://orcid.org/0000-0001-8871-6254
Fina ClimentDepartment of Pathology, Hospital Universitari de Bellvitge-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.ORCID https://orcid.org/0000-0002-4360-8388
Laurence de LevalDepartment of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.ORCID https://orcid.org/0000-0003-3994-516X
Stefan DirnhoferInstitute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
Lorenzo LeonciniDepartment of Medical Biotechnology, Section of Pathology, University of Siena, Siena, Italy.
Siok-Bian NgDepartment of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID https://orcid.org/0000-0001-6051-6410
Sarah L OndrejkaPathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0001-9431-2889
Leticia Quintanilla-MartinezInstitute of Pathology and Neuropathology, Eberhard Karls University of Tübingen and Comprehensive Cancer Center, University Hospital Tübingen, Tübingen, Germany.ORCID https://orcid.org/0000-0001-7156-5365
Lorinda SomaDepartment of Pathology, City of Hope Medical Center, Duarte, CA, USA.ORCID https://orcid.org/0000-0003-0606-899X
Andrew WotherspoonDepartment of Histopathology, Royal Marsden Hospital, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Session 3 of the lymphoma workshop of the XXI joint meeting of the European Association for Haematopathology and the Society for Hematopathology took place in Florence, Italy, on September 22, 2022. The topics of this session were splenic and nodal marginal zone lymphomas, transformation in marginal zone lymphomas, and pediatric nodal marginal zone lymphomas and their differential diagnosis as well as related entities. Forty-two cases in these categories were submitted to the workshop, including splenic lymphomas (marginal zone and diffuse red pulp lymphomas), transformed marginal zone lymphomas (splenic and nodal), nodal marginal zone lymphomas with increased TFH-cells, and pediatric nodal marginal zone lymphomas. The case review highlighted some of the principal problems in the diagnosis of marginal zone lymphomas, including the difficulties in the distinction between splenic marginal zone lymphoma, splenic diffuse red pulp lymphoma, and hairy cell leukemia variant/splenic B-cell lymphoma with prominent nucleoli which requires integration of clinical features, immunophenotype, and morphology in blood, bone marrow, and spleen; cases of marginal zone lymphoma with markedly increased TFH-cells, simulating a T-cell lymphoma, where molecular studies (clonality and mutation detection) can help to establish the final diagnosis; the criteria for transformation of marginal zone lymphomas, which are still unclear and might require the integration of morphological and molecular data; the concept of an overlapping spectrum between pediatric nodal marginal zone lymphoma and pediatric-type follicular lymphoma; and the distinction between pediatric nodal marginal zone lymphoma and "atypical" marginal zone hyperplasia, where molecular studies are mandatory to correctly classify cases.

Indexed as

Leukemia, Lymphocytic, Chronic, B-CellLymphoma, B-Cell, Marginal ZoneLymphoma, FollicularSplenic NeoplasmsBone MarrowChildHumansHyperplasiaSpleenMarginal zone lymphomaMarginal zone lymphoma transformationPediatric nodal marginal zone hyperplasiaPediatric nodal marginal zone lymphomaSplenic diffuse red pulp small B-cell lymphomaSplenic marginal zone lymphoma

Identifiers

PMID37656249
PMCPMC10542713

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.