Evidence map›Paper›PMID 37656166›Full record

ArticleJournal of animal science2023

Integrative analyses of the mRNA expression profile reveal the involvement of STC1 in chicken folliculogenesis.

Junwei Sun, Pengwei Zhang, Dongxue Wang, Shuaipeng Zhu, Xiangfei Ma, Zhenwei Du, Jiechang Zhang, Shuangyuan Yang, Hetian Huang, Ruirui Jiang and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Junwei SunCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Pengwei ZhangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Dongxue WangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Shuaipeng ZhuCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Xiangfei MaCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Zhenwei DuCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Jiechang ZhangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Shuangyuan YangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Hetian HuangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Ruirui JiangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Yadong TianCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Wenting LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Xiangtao KangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Fengbin YanCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Guirong SunCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Donghua LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Henan Agricultural University · CN

Funding

China Agriculture Research System CARS-40-K04Key Research Project of the Shennong Laboratory SN01-2022-05National Natural Science Foundation of China 32072710
6 · The paper itself

Abstract

Efficient ovarian follicle development, maturation, and ovulation are critical for egg production performance. Previous research has underscored the importance of messenger RNAs (mRNAs) in regulating development and folliculogenesis in chicken ovarians. However, the molecular mechanism is not fully understood, especially in the late period of the laying cycle. In the present study, ovarian tissues from 80-week-old Hy-Line Brown layers (three with high and three with low rates of egg laying) were collected for transcriptome sequencing. A total of 306 differentially expressed genes (DEGs) were identified in this study, at a false discovery rate (FDR)-corrected P-value < 0.05 and a log2|fold change| (log2|FC|) ≥1.5. Among these DEGs, stanniocalcin 1 (STC1) was mainly related to cellular processes, single-organism processes, biological regulation, metabolic processes, developmental processes, and reproductive processes. Then, we further investigated the regulation of STC1 during chicken follicle development and found that STC1 inhibited the proliferation and stimulated the apoptosis of follicular granulosa cells (GCs), and decreased the expression of progesterone (P4) and estradiol (E2). Collectively, these results suggest that STC1 plays an important role in chicken follicle development by decreasing GC proliferation and steroidogenesis and stimulating GC apoptosis. This study contributes to the understanding of the reproductive biology of laying hens in the late period of the laying cycle and further lays a foundation for the improvement of egg production in poultry breeding.

Indexed as

ChickensGlycoproteinsAnimalsApoptosisFemaleRNA, MessengerGlycoproteinsRNA, Messengerteleocalcinchickenegg productionovarySTC1transcriptome sequencing

Identifiers

PMID37656166
PMCPMC10503649
OpenAlexW4386346461

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.