Evidence map›Paper›PMID 37655588›Full record

ArticleThe Australian and New Zealand journal of psychiatry2023

Preliminary results from the Australian Genetics of Bipolar Disorder Study: A nation-wide cohort.

Penelope A Lind, Dan J Siskind, Ian B Hickie, Lucía Colodro-Conde, Simone Cross, Richard Parker, Nicholas G Martin, Sarah E Medland

Open access · hybridAbstract read
In one paragraph

Article in The Australian and New Zealand journal of psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Penelope A LindPsychiatric Genetics, Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID 0000-0002-3887-2598
Dan J SiskindSchool of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.
Ian B HickieBrain and Mind Centre, The University of Sydney, Camperdown, NSW, Australia.ORCID 0000-0001-8832-9895
Lucía Colodro-CondePsychiatric Genetics, Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Simone CrossPsychiatric Genetics, Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Richard ParkerPsychiatric Genetics, Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID 0000-0003-1451-5622
Nicholas G MartinGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Sarah E MedlandPsychiatric Genetics, Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID 0000-0003-1382-380X
QIMR Berghofer Medical Research Institute · AUThe University of Queensland · AUQueensland University of Technology · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe Australian Genetics of Bipolar Disorder Study is a nation-wide cohort of adults living with bipolar disorder. The study aims to detect the relationships between genetic risk, symptom severity, and the lifetime prevalence of bipolar disorder, treatment response and medication side effects, and patterns and costs of health care usage.

methodsA total of 6682 participants (68.3% female; aged 44.8 ± 13.6 years [range = 18-90]) were recruited in three waves: a nation-wide media campaign, a mail-out based on prescriptions for lithium carbonate and through the Australian Genetics of Depression Study. Participants completed a self-report questionnaire. A total of 4706 (70%) participants provided a saliva sample and were genotyped and 5506 (82%) consented to record linkage of their Pharmaceutical and Medicare Benefits Schedule data.

resultsMost participants were living with bipolar I disorder (

conclusionOur findings highlight the high rate of comorbidities and adverse drug reactions among adults living with bipolar disorder in the general Australian population. Future genomic analyses focus on identifying genetic variants influencing pharmacotherapy treatment response and side effects.

Indexed as

Bipolar DisorderDrug-Related Side Effects and Adverse ReactionsAdultAgedAustraliaFemaleHumansLithium CarbonateMaleNational Health ProgramsYoung AdultLithium Carbonateadverse drug reactionsAustraliaBipolar disordercomorbidity

Identifiers

PMID37655588
PMCPMC10619176
OpenAlexW4386347515

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.