Evidence map›Paper›PMID 37655448›Full record

ArticleGut microbes2023

Ring1a protects against colitis through regulating mucosal immune system and colonic microbial ecology.

Yashu Wang, Qianru Li, Jiayu Zhang, Pingping Liu, Huaixin Zheng, Lijuan Chen, Zhen Wang, Chen Tan, Min Zhang, Hongxia Zhang and 5 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Gut microbes · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Yashu WangDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Qianru LiDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Jiayu ZhangLab of Pathology, Hebei Medical University, Shijiazhuang, China.
Pingping LiuDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Huaixin ZhengDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Lijuan ChenShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-omics of MARA, Kunpeng Institute of Modern Agriculture at Foshan, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.
Zhen WangShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-omics of MARA, Kunpeng Institute of Modern Agriculture at Foshan, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.
Chen TanDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Min ZhangDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Hongxia ZhangDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Wenqing MiaoDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Yuke WangDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Xiaoyan XuanDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Guoqiang YiShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-omics of MARA, Kunpeng Institute of Modern Agriculture at Foshan, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.
Peng WangDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.ORCID 0000-0003-1845-7589
Zhengzhou University · CNAgricultural Genomics Institute at Shenzhen · CNHebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) represents a prominent chronic immune-mediated inflammatory disorder, yet its etiology remains poorly comprehended, encompassing intricate interactions between genetics, immunity, and the gut microbiome. This study uncovers a novel colitis-associated risk gene, namely Ring1a, which regulates the mucosal immune response and intestinal microbiota. Ring1a deficiency exacerbates colitis by impairing the immune system. Concomitantly, Ring1a deficiency led to a

Indexed as

ColitisGastrointestinal MicrobiomeAnimalsImmune SystemMetronidazoleMicePolycomb Repressive Complex 1PrevotellaMetronidazolePolycomb Repressive Complex 1Ring1 protein, mouseDSS colitisintestinal microbiotamucosal immune systemRing1ascRNA-seq

Identifiers

PMID37655448
PMCPMC10478745
OpenAlexW4386346765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.