ArticleFrontiers in microbiology2023
Mendelian randomization supports causality between gut microbiota and chronic hepatitis B.
Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- HBV and the Microbiome-PubMed Database Literature Review.Infectious disease reports · 2026Review
- Supplementation with Xinjiang licorice extract in diets enhanced the growth performance and intestinal immunity of broilers.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- CCL20 mediates the effect of cathepsin S on hepatocellular carcinoma development insights from Mendelian randomization and bioinformatics analysis.Discover oncology · 2025Article
- Investigating Correlation Between Gut Microbiota and Rheumatoid Arthritis Subtypes by Mendelian Randomization.Pathogens (Basel, Switzerland) · 2025Article
- Species-level enterosignatures predict clinical phenotypes in chronic hepatitis B and causal triangulation of gut-metabolite-CHB interactions.Frontiers in microbiology · 2025Article
- The Role ofMicroorganisms · 2024Review
- A study on the causal relationship between the gut microbiome and herpes zoster using Mendelian randomization.Frontiers in medicine · 2024Article
- Mendelian Randomization Highlights Gut Microbiota of Short-chain Fatty Acids' Producer as Protective Factor of Cerebrovascular Disease.Current neurovascular research · 2024Article
- Association between gut microbiota and diabetic nephropathy: a mendelian randomization study.Frontiers in microbiology · 2024Article
- Genetic insights into gut microbiota and risk of prostatitis: a Mendelian randomization study.Frontiers in microbiology · 2024Article
- A Mendelian randomization study investigating causal links between gut microbiota or metabolites and chronic hepatitis B.Frontiers in public health · 2024Article
- Causal impact of gut microbiota on five liver diseases: insights from mendelian randomization and single-cell RNA sequencing.Frontiers in genetics · 2024Article
- The Dose-Response Effect of Fluoride Exposure on the Gut Microbiome and Its Functional Pathways in Rats.Metabolites · 2023Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Observational studies have provided evidence of a close association between gut microbiota and the progression of chronic hepatitis B (CHB). However, establishing a causal relationship between gut microbiota and CHB remains a subject of investigation. Methods: Genome-wide association study (GWAS) summary data of gut microbiota came from the MiBioGen consortium, while the GWAS summary data of CHB came from the Medical Research Council Integrative Epidemiology Unit (IEU) Open GWAS project. Based on the maximum likelihood (ML), Mendelian randomization (MR)-Egger regression, inverse variance weighted (IVW), MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO), and weighted-mode and weighted-median methods, we conducted a bidirectional, two-sample, MR analysis to explore the causal relationship between the gut microbiota and CHB. Additionally, we evaluated the genetic associations between individual gut microbes and CHB using the Linkage disequilibrium score regression (LDSC) program. Results: According to the IVW method estimates, genetically predicted class Alphaproteobacteria (odds ratio [OR] = 0.57; 95% confidence interval [CI], 0.34-0.96; false discovery rate [FDR] = 0.046), genus Conclusion: In this study, we identified three types of gut microbiota with a protective effect on CHB and five types with an adverse impact on CHB. We postulate that this information will facilitate the clinical prevention and treatment of CHB through fecal microbiota transplantation.
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