Evidence map›Paper›PMID 37655329›Full record

ArticleActa pharmaceutica Sinica. B2023

P450-mediated dehydrotyrosine formation during WS9326 biosynthesis proceeds

Songya Zhang, Lin Zhang, Anja Greule, Julien Tailhades, Edward Marschall, Panward Prasongpholchai, Daniel J Leng, Jingfan Zhang, Jing Zhu, Joe A Kaczmarski and 9 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 5 countries.

Songya ZhangCAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Lin ZhangInstitut für Biochemie, Albert-Ludwigs-Universität Freiburg, Freiburg 79104, Germany.
Anja GreuleDepartment of Biochemistry and Molecular Biology, the Monash Biomedicine Discovery Institute, Monash University, Clayton 3800, VIC, Australia.
Julien TailhadesDepartment of Biochemistry and Molecular Biology, the Monash Biomedicine Discovery Institute, Monash University, Clayton 3800, VIC, Australia.
Edward MarschallDepartment of Biochemistry and Molecular Biology, the Monash Biomedicine Discovery Institute, Monash University, Clayton 3800, VIC, Australia.
Panward PrasongpholchaiDepartment of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.
Daniel J LengDepartment of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.
Jingfan ZhangSchool of Life Sciences, University of Warwick, Gibbet Hill Campus, Coventry CV4 7AL, UK.
Jing ZhuCAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Joe A KaczmarskiResearch School of Chemistry, the Australian National University, Acton 2601, ACT, Australia.
Ralf B SchittenhelmDepartment of Biochemistry and Molecular Biology, the Monash Biomedicine Discovery Institute, Monash University, Clayton 3800, VIC, Australia.
Oliver EinsleInstitut für Biochemie, Albert-Ludwigs-Universität Freiburg, Freiburg 79104, Germany.
Colin J JacksonARC Centre of Excellence for Innovations in Peptide and Protein Science, Clayton 3800, VIC, Australia.
Fabrizio AlbertiDepartment of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.
Andreas BechtholdInstitute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg 79104, Germany.
Youming ZhangCAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Manuela TosinDepartment of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.
Tong SiCAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Max J CryleDepartment of Biochemistry and Molecular Biology, the Monash Biomedicine Discovery Institute, Monash University, Clayton 3800, VIC, Australia.
Discovery Institute · USUniversity of Warwick · GBChinese Academy of Sciences · CNUniversity of Freiburg · DEAustralian National University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

WS9326A is a peptide antibiotic containing a highly unusual

Indexed as

Cytochrome P450Enzyme mechanismNatural productsNon-ribosomal peptide synthetasePeptide antibioticProtein crystal structure

Identifiers

PMID37655329
PMCPMC10465960
OpenAlexW4361283713

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.